MAPPING THE BETA-NGF GENE INSITU TO A MICROCHROMOSOME IN CHICKEN

被引：11

作者：

DOMINGUEZSTEGLICH, M

LICHTER, P

CARRIER, A

AUFFRAY, C

SCHMID, M

机构：

[1] GERMAN CANC RES CTR,INST VIRUSFORSCH,W-6900 HEIDELBERG 1,GERMANY

[2] COLL FRANCE,NOGENT SUR MARNE,FRANCE

[3] CNRS,INST EMBRYOL,F-94130 NOGENT SUR MARNE,FRANCE

来源：

GENOMICS | 1992年 / 12卷 / 04期

关键词：

D O I：

10.1016/0888-7543(92)90318-M

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The chicken nerve growth factor (βNGF) gene has been mapped by fluorescent in situ hybridization to a pair of microchromosomes, confirming previous reports of the existence of a single gene locus. A 39-kb genomic fragment cloned in a cosmid vector and including the 5′ end of the βNGF locus was biotinylated for nonradioactive detection of the gene. This report adds to the increasing evidence proving microchromosomal localization of highly conserved and biologically fundamental genes. The implications of such genes belonging to very small linkage groups for the transmission of alleles from generation to generation together with the relevance of nonisotopic in situ hybridization for avian gene mapping are considered. © 1992.

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页码：829 / 832

页数：4

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