SEX-DIFFERENCES IN MICRONUCLEUS INDUCTION WITH HYCANTHONE METHANESULFONATE IN BONE-MARROW CELLS OF MICE

被引：8

作者：

KLIESCH, U ^{[1
]}

ADLER, ID ^{[1
]}

机构：

[1] GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT GMBH, INST SAUGETIERGENET, W-8042 NEUHERBERG, GERMANY

来源：

MUTATION RESEARCH | 1992年 / 283卷 / 04期

关键词：

SEX DIFFERENCE; MICRONUCLEUS INDUCTION; HYCANTHONE METHANESULFONATE; (MICE; BONE-MARROW CELLS);

D O I：

10.1016/0165-7992(92)90056-N

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The clastogenic effect of the antischistosomal drug hycanthone methanesulfonate was studied with the micronucleus test in mouse bone marrow cells. Male and female (102/El x C3H/El)F1 mice were treated with single i.p. injections. Bone marrow was sampled 18, 24 and 30 h after treatment with 100 mg/kg. The highest micronucleus yield occurred at 24 h. The dose response for micronucleus induction at 24 h after treatment was non-linear for doses between 5 and 300 mg/kg. The lowest effective dose was 5 mg/kg for females and 10 mg/kg for males. The experiments revealed a significantly higher sensitivity of female mice for the induction of micronuclei in polychromatic erythrocytes by hycanthone methane-sulfonate. This result supports the recommendation to use both sexes for quantitative assessment of genotoxicity in the micronucleus test.

引用

页码：249 / 253

页数：5

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