SINGLE AND MULTIPLE-DOSE PHARMACOKINETICS OF LANSOPRAZOLE IN ELDERLY SUBJECTS

被引：26

作者：

FLOUVAT, B

DELHOTALLANDES, B

COURNOT, A

DELLATOLAS, F

机构：

[1] THERAPHARM RECH,F-92100 BOULOGNE BILLANCO,FRANCE

[2] HOUDE LABS,F-92080 PARIS,FRANCE

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1993年 / 36卷 / 05期

关键词：

LANSOPRAZOLE; PHARMACOKINETICS; ELDERLY SUBJECTS; MULTIPLE DOSE;

D O I：

10.1111/j.1365-2125.1993.tb00398.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Plasma concentrations of lansoprazole and of its sulphone, sulphide a-nd 5-hydroxylated metabolites were determined after oral administration of a single 30 mg dose and after 7 days of treatment with a daily 30 mg dose in 12 elderly subjects (mean age 83 years). Results after a single dose were compared with those from a historical control group of 18 young subjects (mean age 23 years). Mean values of AUC after single dose were 2668 ng ml-1 h in the young subjects and 5216 ng ml-1 h in the elderly (P < 0.05). Mean t1/2z values in young and elderly subjects were 1.4 h and 2.9 h, respectively (P < 0.001). Plasma concentrations of the metabolites were similar in both groups. However, the hydroxylated metabolite of the sulphone was detected only in elderly subjects. Steady state plasma concentrations of lansoprazole were reached after 3 days of dosing with lansoprazole. The accumulation ratio was 1.31 in the elderly subjects.

引用

页码：467 / 469

页数：3