REGIONAL ADOPTIVE IMMUNOTHERAPY WITH INTERLEUKIN-2 AND LYMPHOKINE-ACTIVATED KILLER (LAK) CELLS FOR LIVER METASTASES

被引：37

作者：

KEILHOLZ, U

SCHEIBENBOGEN, C

BRADO, M

GEORGI, P

MACLACHLAN, D

BRADO, B

HUNSTEIN, W

机构：

[1] UNIV HEIDELBERG,DEPT RADIOL,DIV RADIODIAGNOST,D-69115 HEIDELBERG,GERMANY

[2] UNIV HEIDELBERG,DEPT NUCL MED,D-69115 HEIDELBERG,GERMANY

来源：

EUROPEAN JOURNAL OF CANCER | 1994年 / 30A卷 / 01期

关键词：

D O I：

10.1016/S0959-8049(05)80028-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A phase Ib trial of a novel regional approach to adoptive immunotherapy is reported. Patients with liver metastases received continuous high-dose infusion of interleukin-2 (IL-2) into the splenic artery or intravenous infusion with subsequent transfer of lymphokine-activated killer (LAK) cells into the portal vein or the hepatic artery. Trafficking studies revealed homogenous distribution of the LAK cells within the liver. The usual side-effects of IL-2 and LAK cells occurred without limiting liver toxicity. One partial (7+ months) and two complete responses (36 and 26+ months) were observed id 9 patients with metastases from cutaneous melanoma. None of 6 patients with metastases from ocular melanoma responded.

引用

页码：103 / 105

页数：3

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