A POSSIBLE NEW LOCUS OF ALKALINE-PHOSPHATASE EXPRESSED IN HUMAN TESTIS

被引：39

作者：

MILLAN, JL ^{[1
]}

ERIKSSON, A ^{[1
]}

STIGBRAND, T ^{[1
]}

机构：

[1] UNIV UMEA, INST FORENS MED, S-90006 UMEA, SWEDEN

来源：

HUMAN GENETICS | 1982年 / 62卷 / 04期

关键词：

D O I：

10.1007/BF00304541

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human testes contain trace amounts of heat-stable placental-like alkaline phosphatase. Using a recently described allotype-specific monoclonal antibody (F11) toward placental alkaline phosphatase (PLAP), shows that the frequencies of reactivity of the testis enzymes differ greatly from those of the placental phenotypes. By means of the enzyme inhibitors L-Phe, L-Phe-Gly-Gly, L-Leu and L-Leu-Gly-Gly, the testis enzyme can be clearly distinguished in all cases from the placental enzyme. The testis enzyme is apparently not a product of the placental gene and suggest the possible existence of a new locus of alkaline phosphatase.

引用

页码：293 / 295

页数：3

共 11 条

[1]

BECKMAN G, 1975, HEREDITAS, V81, P85

[2]

CHANG CH, 1980, CANCER RES, V40, P1506

[3] L-LEUCINE, A SPECIFIC INHIBITOR OF A RARE HUMAN PLACENTAL ALKALINE-PHOSPHATASE PHENOTYPE [J].