Direct vascular actions of quercetin in aorta from renal hypertensive rats

被引：28

作者：

Choi, Seok ^{[1
]}

Ryu, Kwon Ho ^{[2
]}

Park, Sang Hag ^{[2
]}

Jun, Jae Yeoul ^{[1
]}

Shin, Byung Chul ^{[3
]}

Chung, Jong Hoon ^{[3
]}

Yeum, Cheol Ho ^{[1
]}

机构：

[1] Chosun Univ, Coll Med, Dept Physiol, 309 Pilmundaero, Kwangju 501759, South Korea

[2] Chosun Univ, Coll Med, Dept Psychiat, Kwangju 501759, South Korea

[3] Chosun Univ, Coll Med, Dept Internal Med, Kwangju 501759, South Korea

来源：

KIDNEY RESEARCH AND CLINICAL PRACTICE | 2016年 / 35卷 / 01期

关键词：

Antioxidant; Quercetin; Renal hypertension;

D O I：

10.1016/j.krcp.2015.12.003

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Background: Chronic treatment with the dietary flavonoid quercetin is known to lower blood pressure and restore endothelial dysfunction in animal models of hypertension. This study investigated the direct effects of quercetin on vascular response in chronic 2-kidney, 1-clip (2K1C) renal hypertensive rats. The effects of antioxidant vitamin ascorbic acid on the vasoreactivity were also examined. Methods: 2K1C renal hypertension was induced by clipping the left renal artery; age-matched rats that received sham treatment served as controls. Thoracic aortae were mounted in tissue baths for the measurement of isometric tension. Results: Relaxant responses to acetylcholine were significantly attenuated in 2K1C rats in comparison with sham rats. Quercetin or ascorbic acid augmented acetylcholine-induced relaxation in 2K1C rats, whereas no significant differences were noted in sham rats. The relaxation response to sodium nitroprusside was comparable between 2K1C and sham rats, and sodium nitroprusside-induced relaxation was not altered by quercetin or ascorbic acid in either group. The contractile response to phenylephrine was significantly enhanced in 2K1C rats compared with sham rats. Phenylephrine-induced contraction was inhibited by pretreatment with quercetin or ascorbic acid in 2K1C rats, whereas neither chemical affected responses in sham rats. Nw-nitro-L-arginine methyl ester markedly augmented the contractile response to phenylephrine in sham rats, whereas no significant differences were observed in 2K1C rats. Quercetin or ascorbic acid did not affect phenylephrine-induced contraction in the presence of Nw-nitro-L-arginine methyl ester in either 2K1C or sham rats. Conclusion: Acute exposure to quercetin appears to improve endothelium-dependent relaxation and inhibit the contractile response, similar to the effect of ascorbic acid in 2K1C hypertension. These results partially explain the vascular beneficial effects of quercetin in renal hypertension. Copyright (C) 2016. The Korean Society of Nephrology. Published by Elsevier.

引用

页码：15 / 21

页数：7

共 29 条

[1]

Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: Comparative study with ascorbic acid [J].