MURINE DEVELOPMENTAL CONTROL GENES

被引：563

作者：

KESSEL, M

GRUSS, P

机构：

[1] Max-Planck-Institute of Biophysical Chemistry, Department of Molecular Cell Biology

来源：

SCIENCE | 1990年 / 249卷 / 4967期

关键词：

D O I：

10.1126/science.1974085

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Various strategies have been used to isolate genes that participate in the regulation of mouse development. Gene families that have been identified on the basis of their homology to motifs within Drosophila control genes or human transcription factor genes, namely homeobox (Hox), paired-box (Pax), and POU genes, can be compared with respect to gene organization, structure, and expression patterns. The functions of these genes can be analyzed molecularly in vitro and in vivo with the use of available mouse mutants or transgenic mice. In addition, it has been possible to generate gain- or loss-of-function mutations by random or targeted introduction of trans-genes. Models derived from these studies can reveal the successive steps of developmental control on a genetic level.

引用

页码：374 / 379

页数：6

共 114 条

[1] THE HUMAN HOX GENE FAMILY [J].