B16 MELANOMA RESPONSE INVIVO TO PHOTOCHEMOTHERAPY WITH MITOXANTRONE AND RED-LIGHT

被引：5

作者：

ANDREONI, A

CANTI, G

FABBROCINI, G

MASTROCINQUE, M

QUARTO, E

机构：

[1] NAPLES UNIV, DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC, I-80131 NAPLES, ITALY

[2] UNIV MILAN, DIPARTMENTO FARMACOL, I-20129 MILAN, ITALY

来源：

CANCER LETTERS | 1991年 / 61卷 / 01期

关键词：

PHOTOCHEMOTHERAPY; B16; MELANOMA; TUMOR PHOTOSENSITIZATION; MITOXANTRONE; ANTITUMOR DRUGS; ANTHRACENEDIONES;

D O I：

10.1016/0304-3835(91)90081-R

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cytocidal activity of light-activated mitoxantrone in mice bearing B16 melanoma was investigated. Mice inoculated with 10(6) tumor cells on day 0 were i.p. injected with 1 mg/kg body weight of mitoxantrone on days 1, 5 and 9 and exposed to 108 J/cm2 of suitably filtered red light from a halogen lamp on days 2, 6 and 10. The treatment significantly prolonged the median survival time compared to both therapy with mitoxantrone and with red light alone.

引用

页码：89 / 94

页数：6

共 20 条

[1] ENHANCEMENT OF ANTITUMOR DRUG CYTOTOXICITY VIA LASER PHOTOACTIVATION [J].