IMMOBILIZATION OF HUMAN THROMBOMODULIN ON GLASS-BEADS AND ITS ANTICOAGULANT ACTIVITY

被引：31

作者：

AKASHI, M

MARUYAMA, I

FUKUDOME, N

YASHIMA, E

机构：

[1] MIYAKONOJO NATL COLL TECHNOL,DEPT IND CHEM,MIYAZAKI 885,JAPAN

[2] KAGOSHIMA UNIV,FAC MED,DEPT INTERNAL MED 3,KAGOSHIMA 890,JAPAN

来源：

BIOCONJUGATE CHEMISTRY | 1992年 / 3卷 / 05期

关键词：

D O I：

10.1021/bc00017a002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Human thrombomodulin (TM) was for the first time immobilized on glass beads by the reaction between the carboxyl group of TM and the amino group of glass beads using water-soluble carbodiimide. Immobilized human TM exhibited both anticoagulant activity and inhibition of platelet aggregation of human blood.

引用

页码：363 / 365

页数：3

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