PREDICTION OF CARBAZOLE SOLUBILITY AND ITS DEPENDENCE UPON THE SOLVENT NATURE

被引：55

作者：

RUELLE, P

SARRAF, E

KESSELRING, UW

机构：

[1] Institut d'Analyse Pharmaceutique, Ecole de Pharmacie, Université de Lausanne, CH-1015 Lausanne, B E P

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 104卷 / 02期

关键词：

CARBAZOLE; SOLUBILITY PREDICTION; MOBILE ORDER THEORY; HYDROGEN BOND; STABILITY CONSTANT; SOLVENT EFFECT;

D O I：

10.1016/0378-5173(94)90187-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

On the basis of at most three parameters, the solubility of carbazole is predicted in 33 nonelectrolyte solvents by means of the general solubility equation derived from the thermodynamics of mobile order. Particular attention is focussed on the influence of the formation of solute-solvent stoechiometrical hydrogen bonds on the treatment of the non-specific dipole-dipole and dispersion interactions. Three classes of solvents can be distinguished according to their solubilizing potential towards carbazole: non-complexing solvents, complexing non-associated solvents and complexing amphiphilic solvents. The analysis of the relative importance of the different terms contributing to the solubility allows one to quantitatively understand its variation between the different classes as well as within each class of solvents.

引用

页码：125 / 133

页数：9

共 23 条

[1] THERMOCHEMICAL INVESTIGATIONS OF ASSOCIATED SOLUTIONS .5. CALCULATION OF SOLUTE-SOLVENT EQUILIBRIUM-CONSTANTS FROM SOLUBILITY IN MIXTURES CONTAINING 2 COMPLEXING SOLVENTS [J].