EFFECT OF A SINGLE REPLACEMENT OF ONE OF RINGER LACTATE, HYPERTONIC SALINE DEXTRAN, 7G-PERCENT ALBUMIN, STROMA-FREE HEMOGLOBIN, O-RAFFINOSE POLYHEMOGLOBIN OR WHOLE-BLOOD ON THE LONG-TERM SURVIVAL OF UNANESTHETIZED RATS WITH LETHAL HEMORRHAGIC-SHOCK AFTER 67-PERCENT ACUTE BLOOD-LOSS

This study is based on an unanesthetized lethal hemorrhagic shock rat model (67% blood volume bled in 2 stages). The 8 groups studied were as follows. 1. Control - no resuscitation fluid. 2.Reinfusion of rat's own shed whole blood. 3.Ringer lactate solution - 3 times shed blood volume. The following 4 fluids were each given as equal to the shed blood volume. 4. 7.5g% NaCl hypertonic saline /6% Dextran 70 followed by 3 volumes Ringer lactate dextran. 5. Ringer lactate solution. 6. Human albumin 7 g% in Ringer lactate. 7. Stroma-free hemoglobin in Ringer lactate 8. o-raffinose polyhemoglobin in Ringer Lactate. Blood pressure and other vital signs were recorded continuously during the control period, bleeding periods , infusion period and 60 minutes after infusion. After this all surviving animals were followed for 14 days with no other special treatments. Group 4 had transient (10 minutes) returned of blood pressure to control levels. The 3 groups with sustained blood pressure at control level when followed for 1 hour were groups 2, 6 and 7. The 2 groups with 100% survival on days 14 were group 2 and group 7.