POSITRON EMISSION TOMOGRAPHY IN FAMILIAL ALZHEIMER-DISEASE

被引：28

作者：

KENNEDY, AM

ROSSOR, MN

FRACKOWIAK, RSJ

机构：

[1] HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT,LONDON W12 0HS,ENGLAND

[2] NATL HOSP NEUROL & NEUROSURG,LONDON WC1N 3BG,ENGLAND

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 1995年 / 9卷 / 01期

关键词：

POSITRON EMISSION TOMOGRAPHY; FAMILIAL ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN; CHROMOSOME; 14; LINKAGE;

D O I：

10.1097/00002093-199505000-00005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is increasing evidence for genetic heterogeneity in Alzheimer disease. A longitudinal clinical and imaging study had been established in order to determine whether specific phenotypic profiles are present in aetiologically distinct familial Alzheimer disease (FAD) pedigrees. [F-18]fluorodeoxyglucose positron emission tomography has been used in conjunction with statistical parametric mapping to determine the relative distribution of hypometabolism. A parietotemporal deficit has been observed in individuals from both amyloid precursor protein mutation and chromosome 14 linked FAD families. Preliminary data from asymptomatic individuals at risk of FAD shows similar, although a less extensive pattern of deficit.

引用

收藏

页码：17 / 20

页数：4

相关论文

共 33 条

[1]

ADAMS R, 1989, J NEURAL TRANSM-PARK, V1, P36

[2] EARLY DETECTION OF ALZHEIMERS-DISEASE - A STATISTICAL APPROACH USING POSITRON EMISSION TOMOGRAPHIC DATA [J].

AZARI, NP ;

PETTIGREW, KD ;

SCHAPIRO, MB ;

HAXBY, JV ;

GRADY, CL ;

PIETRINI, P ;

SALERNO, JA ;

HESTON, LL ;

RAPOPORT, SI ;

HORWITZ, B .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1993, 13 (03) :438-447

[3] FAMILIAL ALZHEIMERS-DISEASE IN AMERICAN DESCENDANTS OF THE VOLGA GERMANS - PROBABLE GENETIC FOUNDER EFFECT [J].

BIRD, TD ;

LAMPE, TH ;

NEMENS, EJ ;

MINER, GW ;

SUMI, SM ;

SCHELLENBERG, GD .

ANNALS OF NEUROLOGY, 1988, 23 (01) :25-31

[4] CASE-CONTROL STUDY OF LATE ONSET PROBABLE ALZHEIMERS-DISEASE [J].

CHANDRA, V ;

PHILIPOSE, V ;

BELL, PA ;

LAZAROFF, A ;

SCHOENBERG, BS .

NEUROLOGY, 1987, 37 (08) :1295-1300

[5] STUDIES IN AGING OF THE BRAIN .4. FAMILIAL ALZHEIMER-DISEASE - RELATION TO TRANSMISSIBLE DEMENTIA, ANEUPLOIDY, AND MICROTUBULAR DEFECTS [J].

COOK, RH ;

WARD, BE ;

AUSTIN, JH .

NEUROLOGY, 1979, 29 (10) :1402-1412

[6] BRAIN METABOLISM AS MEASURED WITH POSITRON EMISSION TOMOGRAPHY - SERIAL ASSESSMENT IN A PATIENT WITH FAMILIAL ALZHEIMERS-DISEASE [J].

CUTLER, NR ;

HAXBY, JV ;

DUARA, R ;

GRADY, CL ;

MOORE, AM ;

PARISI, JE ;

WHITE, J ;

HESTON, L ;

MARGOLIN, RM ;

RAPOPORT, SI .

NEUROLOGY, 1985, 35 (11) :1556-1561

[7]

FELDMAN R, 1962, NEUROLOGY, V13, P811

[8] CEREBRAL MAPPING OF APRAXIA IN ALZHEIMERS-DISEASE BY POSITRON EMISSION TOMOGRAPHY [J].

FOSTER, NL ;

CHASE, TN ;

PATRONAS, NJ ;

GILLESPIE, MM ;

FEDIO, P .

ANNALS OF NEUROLOGY, 1986, 19 (02) :139-143

[9] ALZHEIMERS-DISEASE - FOCAL CORTICAL CHANGES SHOWN BY POSITRON EMISSION TOMOGRAPHY [J].

FOSTER, NL ;

CHASE, TN ;

FEDIO, P ;

PATRONAS, NJ ;

BROOKS, RA ;

DICHIRO, G .

NEUROLOGY, 1983, 33 (08) :961-965

[10] REGIONAL CEREBRAL OXYGEN-SUPPLY AND UTILIZATION IN DEMENTIA - A CLINICAL AND PHYSIOLOGICAL STUDY WITH O-15 AND POSITRON TOMOGRAPHY [J].

FRACKOWIAK, RSJ ;

POZZILLI, C ;

LEGG, NJ ;

DUBOULAY, GH ;

MARSHALL, J ;

LENZI, GL ;

JONES, T .

BRAIN, 1981, 104 (DEC) :753-778

← 1 2 3 4 →