THE APPLICATION OF CELL-CULTURE SYSTEMS IN DRUG DISCOVERY AND DEVELOPMENT

[1] EPITHELIAL TRANSPORT OF DRUGS IN CELL-CULTURE .1. A MODEL FOR STUDYING THE PASSIVE DIFFUSION OF DRUGS OVER INTESTINAL ABSORPTIVE (CACO-2) CELLS [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (06) : 476 - 482

[2] THE USE OF CULTURED EPITHELIAL AND ENDOTHELIAL-CELLS FOR DRUG TRANSPORT AND METABOLISM STUDIES [J]. PHARMACEUTICAL RESEARCH, 1990, 7 (05) : 435 - 451

[3] EVIDENCE FOR A POLARIZED EFFLUX SYSTEM FOR PEPTIDES IN THE APICAL MEMBRANE OF CACO-2 CELLS [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 190 (03) : 760 - 766

[4] ASSOCIATION OF INTESTINAL PEPTIDE-TRANSPORT WITH A PROTEIN RELATED TO THE CADHERIN SUPERFAMILY [J]. SCIENCE, 1994, 264 (5157) : 430 - 433

[5] 127 CULTURED HUMAN TUMOR-CELL LINES PRODUCING TUMORS IN NUDE MICE [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 59 (01): : 221 - 226

[6] HIDALGO IJ, 1989, GASTROENTEROLOGY, V96, P736

[7] CACO-2 CELL MONOLAYERS AS A MODEL FOR DRUG TRANSPORT ACROSS THE INTESTINAL-MUCOSA [J]. PHARMACEUTICAL RESEARCH, 1990, 7 (09) : 902 - 910

[8] IN-VITRO SYSTEMS FOR STUDYING INTESTINAL DRUG ABSORPTION [J]. MEDICINAL RESEARCH REVIEWS, 1995, 15 (02) : 83 - 109

[9] HUNTER J, 1993, J BIOL CHEM, V268, P14991

[10] DISCOVERY OF A PEPTIDE-BASED RENIN INHIBITOR WITH ORAL BIOAVAILABILITY AND EFFICACY [J]. SCIENCE, 1992, 257 (5078) : 1940 - 1943

[1] EPITHELIAL TRANSPORT OF DRUGS IN CELL-CULTURE .1. A MODEL FOR STUDYING THE PASSIVE DIFFUSION OF DRUGS OVER INTESTINAL ABSORPTIVE (CACO-2) CELLS [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (06) : 476 - 482

[2] THE USE OF CULTURED EPITHELIAL AND ENDOTHELIAL-CELLS FOR DRUG TRANSPORT AND METABOLISM STUDIES [J]. PHARMACEUTICAL RESEARCH, 1990, 7 (05) : 435 - 451

[3] EVIDENCE FOR A POLARIZED EFFLUX SYSTEM FOR PEPTIDES IN THE APICAL MEMBRANE OF CACO-2 CELLS [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 190 (03) : 760 - 766

[4] ASSOCIATION OF INTESTINAL PEPTIDE-TRANSPORT WITH A PROTEIN RELATED TO THE CADHERIN SUPERFAMILY [J]. SCIENCE, 1994, 264 (5157) : 430 - 433

[5] 127 CULTURED HUMAN TUMOR-CELL LINES PRODUCING TUMORS IN NUDE MICE [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 59 (01): : 221 - 226

[6] HIDALGO IJ, 1989, GASTROENTEROLOGY, V96, P736

[7] CACO-2 CELL MONOLAYERS AS A MODEL FOR DRUG TRANSPORT ACROSS THE INTESTINAL-MUCOSA [J]. PHARMACEUTICAL RESEARCH, 1990, 7 (09) : 902 - 910

[8] IN-VITRO SYSTEMS FOR STUDYING INTESTINAL DRUG ABSORPTION [J]. MEDICINAL RESEARCH REVIEWS, 1995, 15 (02) : 83 - 109

[9] HUNTER J, 1993, J BIOL CHEM, V268, P14991

[10] DISCOVERY OF A PEPTIDE-BASED RENIN INHIBITOR WITH ORAL BIOAVAILABILITY AND EFFICACY [J]. SCIENCE, 1992, 257 (5078) : 1940 - 1943