EFFECT OF EGF DOSAGE FORMS ON ALKALI-BURNED CORNEAL WOUND-HEALING OF MICE

被引：37

作者：

GONUL, B

ERDOGAN, D

OZOGUL, C

KOZ, M

BABUL, A

CELEBI, N

机构：

[1] Department of Physiology, Gazi University Faculty of Medicine, Ankara

[2] Department of Histology, Gazi University Faculty of Pharmacy, Ankara

[3] Department of Pharmaceutical Technology, Gazi University Faculty of Pharmacy, Ankara

来源：

BURNS | 1995年 / 21卷 / 01期

关键词：

D O I：

10.1016/0305-4179(95)90773-S

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

The local treatment effects of EGF forms on alkali burned mice corneal wounds were identified. The corneal wounds were induced by 0.5 M NaOH solution on the corneal surfaces of the mice. The local epidermal growth factor solutions (100 ng/ml) and gel form in 0.2 per cent w/w carbopol 940 (100 ng/ml) were dropped in 5 mu l aliquots into the eye twice a day. The corneal wounds were measured for 15 days at 7-day intervals and examined his;tologically at the end of 15th day of the experimental period. The results indicated that topical epidermal growth factor treatment in solution improved the healing of alkali burned corneal wounds when compared with epidermal growth factor delivered in a polymer system.

引用

页码：7 / 10

页数：4

共 18 条

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