SYNTHESIS OF 4'-FLUOROADENOSINE AS AN INHIBITOR OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE

被引：23

作者：

GUILLERM, D ^{[1
]}

MUZARD, M ^{[1
]}

ALLART, B ^{[1
]}

GUILLERM, G ^{[1
]}

机构：

[1] UFR SCI REIMS, CHIM BIOORGAN LAB, URA 459, F-51062 REIMS, FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 14期

关键词：

D O I：

10.1016/0960-894X(95)00256-S

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of 4'-Fluoroadenosine was achieved via N-6-benzoyl-9-(5-deoxy-2, 3-O-dibenzoyl-beta-D-erythro-pent-4-enofuranosyl)adenine as intermediate. Evaluation of its inhibitory effect on S-adenosyl-L-homocysteine hydrolase exhibited interesting properties. 4'-Fluoroadenosine caused a time-dependent inactivation of the enzyme, this inactivation was accompanied by reduction of the enzyme-bound NAD(+)(ENAD+) to NADH.

引用

页码：1455 / 1460

页数：6

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