THE CELLULAR FUNCTIONS OF SMALL GTP-BINDING PROTEINS

被引：845

作者：

HALL, A

机构：

[1] Chester Beatty Laboratories, Institute of Cancer Research, London SW3 6JB, Fulham Road

来源：

SCIENCE | 1990年 / 249卷 / 4969期

关键词：

D O I：

10.1126/science.2116664

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A substantial number of novel guanine nucleotide binding regulatory proteins have been identified over the last few years but the function of many of them is largely unknown. This article will discuss a particular family of these proteins, structurally related to the Ras oncoprotein. Approximately 30 Ras-related small guanosine triphosphate (GTP)-binding proteins are known, and from yeast to man they appear to be involved in controlling a diverse set of essential cellular functions including growth, differentiation, cytoskeletal organization, and intracellular vesicle transport and secretion.

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页码：635 / 640

页数：6

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