TRANSLATIONAL CONTROL MEDIATED BY UA-RICH SEQUENCES

被引：50

作者：

KRUYS, V

BEUTLER, B

HUEZ, G

机构：

[1] UNIV LIBRE BRUXELLES,DEPT BIOL MOLEC,CHIM BIOL LAB,RUE CHEVAUX 67,B-1640 RHODE ST GENESE,BELGIUM

[2] UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED CTR,DALLAS,TX 75230

[3] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DALLAS,TX 75230

来源：

ENZYME | 1990年 / 44卷 / 1-4期

关键词：

3'-UNTRANSLATED REGION; MESSENGER RNA DEGRADATION; CYTOKINES; XENOPUS OOCYTES; MACROPHAGES; INTERFERON; TNF; GM-CSF;

D O I：

10.1159/000468757

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several messenger RNAs coding for cytokines, growth factors or oncoproteins contain a conserved UA-rich sequence in their 3' untranslated regions. This sequence, which is composed of several interspersed repeats of the octanucleotide UUAUUUAU, is a key element in the posttranscriptional regulation of these mRNAs. Previously shown to be involved in mRNA destabilization, these UA-rich elements can also strongly influence mRNA translation. A translation inhibition mediated by these sequences has indeed been observed in vitro as well as in frog oocyte or in somatic cells.

引用

页码：193 / 202

页数：10

共 21 条

[1] CONTROL OF CACHECTIN (TUMOR-NECROSIS-FACTOR) SYNTHESIS - MECHANISMS OF ENDOTOXIN RESISTANCE
BEUTLER, B
KROCHIN, N
MILSARK, IW
LUEDKE, C
CERAMI, A
[J]. SCIENCE, 1986, 232 (4753) : 977 - 980
[2] IDENTIFICATION OF A COMMON NUCLEOTIDE-SEQUENCE IN THE 3'-UNTRANSLATED REGION OF MESSENGER-RNA MOLECULES SPECIFYING INFLAMMATORY MEDIATORS
CAPUT, D
BEUTLER, B
HARTOG, K
THAYER, R
BROWNSHIMER, S
CERAMI, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (06) : 1670 - 1674
[3] INDUCTION AND DECAY OF HUMAN FIBROBLAST INTERFERON MESSENGER-RNA
CAVALIERI, RL
HAVELL, EA
VILCEK, J
PESTKA, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (10) : 4415 - 4419
[4] Davidson EH., 1968, GENE ACTIVITY EARLY, P165, DOI [10.1016/B978-1-4832-3185-3.50019-6, DOI 10.1016/B978-1-4832-3185-3.50019-6]
[5] DINTER H, 1987, EMBO J, V7, P599
[6] ENDOTOXIN-RESPONSIVE SEQUENCES CONTROL CACHECTIN TUMOR NECROSIS FACTOR BIOSYNTHESIS AT THE TRANSLATIONAL LEVEL
HAN, J
BROWN, T
BEUTLER, B
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (02) : 465 - 475
[7] SYNERGISTIC INDUCTION OF MESODERM BY FGF AND TGF-BETA AND THE IDENTIFICATION OF AN MESSENGER-RNA CODING FOR FGF IN THE EARLY XENOPUS EMBRYO
KIMELMAN, D
KIRSCHNER, M
[J]. CELL, 1987, 51 (05) : 869 - 877
[8] THE 3' UNTRANSLATED REGION OF THE HUMAN INTERFERON-BETA MESSENGER-RNA HAS AN INHIBITORY EFFECT ON TRANSLATION
KRUYS, V
WATHELET, M
POUPART, P
CONTRERAS, R
FIERS, W
CONTENT, J
HUEZ, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (17) : 6030 - 6034
[9] TRANSLATIONAL BLOCKADE IMPOSED BY CYTOKINE-DERIVED UA-RICH SEQUENCES
KRUYS, V
MARINX, O
SHAW, G
DESCHAMPS, J
HUEZ, G
[J]. SCIENCE, 1989, 245 (4920) : 852 - 855
[10] IDENTIFICATION OF A TRANSLATION INHIBITORY ELEMENT (TIE) IN THE 3' UNTRANSLATED REGION OF THE HUMAN INTERFERON-BETA MESSENGER-RNA
KRUYS, VI
WATHELET, MG
HUEZ, GA
[J]. GENE, 1988, 72 (1-2) : 191 - 200

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