LOCALIZATION OF BASIC FIBROBLAST GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN THE RAT-BRAIN

被引：89

作者：

MATSUYAMA, A

IWATA, H

OKUMURA, N

YOSHIDA, S

IMAIZUMI, K

LEE, Y

SHIRAISHI, S

SHIOSAKA, S

机构：

[1] OSAKA UNIV,SCH MED,BIOMED RES CTR,DEPT NEUROANAT,2-2 YAMADAOKA,SUITA,OSAKA 565,JAPAN

[2] EHIME UNIV,DEPT BIOCHEM,MATSUYAMA,EHIME 790,JAPAN

[3] KANSAI UNIV,SCH MED,SUITA,OSAKA 564,JAPAN

来源：

BRAIN RESEARCH | 1992年 / 587卷 / 01期

关键词：

NEURON; FIBER; EPENDYMAL CELL; IMMUNOHISTOCHEMISTRY; IMMUNOBLOTTING; BASIC FIBROBLAST GROWTH FACTOR;

D O I：

10.1016/0006-8993(92)91427-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The immunohistochemical localization of basic fibroblast growth factor (bFGF) was studied in the adult rat brain, using a specific antibody against a synthetic bFGF fragment (the N-terminal 12 residues). Widespread but uneven regional localization of bFGF-like immunoreactive neurons and fibers was observed. Ependymal cells were also stained. The immunoreactive neurons were found in the cerebral cortex, olfactory bulb, septum, basal magnocellular nuclei, thalamus, hypothalamus, globus pallidus, hippocampus, amygdala, red nucleus, central gray of the midbrain, cerebellum, dorsal tegmental area, reticular formation, cranial motor nuclei and spinal cord. Immunoreactive fiber bundles and nerve terminals were also detected. These results indicate that bFGF is produced by or present in a specific neuronal cell population of the central nervous system.

引用

页码：49 / 65

页数：17

共 32 条

[1]

BARDE YA, 1987, BRAIN PEPTIDE UPDATE, V1, P239

[2] PROMINENT EXPRESSION OF ACIDIC FIBROBLAST GROWTH-FACTOR IN MOTOR AND SENSORY NEURONS [J].