SULPIRIDE ANXIOGENIC-LIKE EFFECT INHIBITION BY A D1 DOPAMINE RECEPTOR ANTAGONIST

被引：16

作者：

SIMON, P ^{[1
]}

PANISSAUD, C ^{[1
]}

COSTENTIN, J ^{[1
]}

机构：

[1] FAC MED PHARM ROUEN, UNITE NEUROPSYCHOPHARMACOL, CNRS URA 1170, F-76803 ST ETIENNE DU ROUVRAY, FRANCE

来源：

NEUROREPORT | 1992年 / 3卷 / 10期

关键词：

ANXIOGENIC-LIKE ACTION; SULPIRIDE; SCH; 23390; D1/D2 DOPAMINE RECEPTORS;

D O I：

10.1097/00001756-199210000-00031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE increased latency to explore a white compartment from a black one into which a mouse has been introduced, appears to be correlated with its anxiety level. In this test, the D2 specific dopamine receptor antagonist (+/-) sulpiride dose dependently (5-40) mg kg-1 i.p.) increased this latency. This effect was suppressed by the D1 specific dopamine receptor antagonist SCH 23390 (25 mug kg-1 s.c.) which intrinsically displayed an apparent anxiolytic effect.

引用

页码：941 / 942

页数：2