EPIDERMAL GROWTH-FACTOR ALTERS THE ELECTROLYTE PROFILE OF LACTATING EWES (OVIS-ARIES)

被引：6

作者：

GOW, CB ^{[1
]}

SILVAPULLE, MJ ^{[1
]}

MOORE, GPM ^{[1
]}

机构：

[1] CSIRO, DIV ANIM PROD, BLACKTOWN, NSW 2148, AUSTRALIA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY | 1992年 / 103卷 / 04期

关键词：

D O I：

10.1016/0300-9629(92)90167-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Lactating ewes were treated with mouse epidermal growth factor (EGF) at a dose rate of 0.5 mg/day for 4 days and its effects on the electrolyte profile were observed. 2. There was no effect of EGF on plasma concentrations of sodium or potassium, although urinary and total (in urine and milk) losses of both were reduced. 3. EGF-induced hypocalcaemia was associated with reduced milk calcium secretion and increased urinary calcium excretion whereas EGF-induced hypermapesaemia was associated with reduced urinary and total magnesium losses. 4. Glomerular filtration rate was reduced during EGF infusion. 5. Chronic intravenous EGF infusion affects the electrolyte profile by altering electrolyte secretion by the mammary gland and renal electrolyte excretion.

引用

收藏

页码：687 / 693

页数：7

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