CONTRASTING EFFECTS OF EPINEPHRINE ON FOREARM HEMODYNAMICS AND ARTERIAL PLASMA NOREPINEPHRINE

被引：13

作者：

KJELDSEN, SE

PETRIN, J

WEDER, AB

JULIUS, S

机构：

[1] Department of Internal Medicine, Division of Hypertension, University of Michigan, Ann Arbor, MI

[2] Department of Internal Medicine, Ullevaal Hospital, Oslo

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1993年 / 6卷 / 05期

关键词：

BLOOD PRESSURE; FOREARM VASODILATION; EPINEPHRINE; SYMPATHETIC DRIVE; VASCULAR RESISTANCE;

D O I：

10.1093/ajh/6.5.369

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Circulating catecholamines are widely considered to cause vasoconstriction. However, in the present study an intravenous infusion of 0.01 mug/kg/min epinephrine for 10 min in healthy men (n = 40, 20 to 40 years of age), which raised arterial plasma epinephrine from 100 +/- 13 to 231 +/- 22 pg/mL (mean +/- SE), increased forearm blood flow (FBF) from 2.79 +/- 0.17 to 3.45 +/- 0.25 mL/100 mL forearm tissue/min (P <.001), and decreased forearm vascular resistance (FVR) from 37.0 +/- 2.4 to 31.1 +/- 2.1 (arbitrary units). Further stepwise increase in epinephrine infusion rate progressively raised FBF (to a maximum 6.91 +/- 0.46) and decreased FVR (to minimum 16.7 +/- 2.0), and increased arterial plasma norepinephrine by more than 60% (P < .001). Thus, circulating epinephrine in concentrations that can be produced by mental stress has, despite its ability to increase sympathetic drive, a regional vasodilating effect in the human forearm.

引用

页码：369 / 375

页数：7

共 23 条

[1]

Jie K., Van Brummelen P., Vermeij P., Postsynaptic ε1- and ε2-adrenoceptors in human blood vessels: Interactions with exogenous catecholamines, Eur J Clin Pharmacol, 17, pp. 174-181, (1987)

[2]

Bolli P., Kiowski W., Amann F.W., Buhler F.W., Buhler F.R., ADRENALINE AND ENHANCED VASOCONSTRICTION IN PATIENTS WITH ESSENTIAL HYPERTENSION, Pharmacol Toxicol, 63, 1, pp. 41-44, (1988)

[3]

Lande K., Kjeldsen S.E., Os I., Et al., Increased platelet and vascular smooth muscle reactivity to low-dose adrena line infusion in mild essential hypertension, J Hypertens, 6, pp. 219-225, (1988)

[4]

Goldstein D.S., Plasma catecholamines and essential hypertension. An analytical review, Hypertension, 5, pp. 86-99, (1983)

[5]

Rostrup M., Mundal H.H., Westheim A., Eide I., Awareness of high blood pressure increases arterial plasma catecholamines, platelet noradrenaline and adrenergic responses to mental stress, J Hypertens, 9, pp. 159-166, (1991)

[6]

Kjeldsen S.E., Neubig R.R., Weder A.B., Zweifler A.J., The hypertension-coronary heart disease dilemma: The catecholamine-blood platelet connection. Editorial review, J Hypertens, 7, pp. 851-860, (1989)

[7]

Julius S., Gudbrandsson T., Jamerson K., Et al., The hemodynamic link between insulin resistance and hypertension. Hypothesis, J Hypertens, 9, pp. 983-986, (1991)

[8]

Rand M.J., Majewski H., Tung L.H., Activation of pre-junctional β-adrenoceptors by adrenaline acting as a cotransmitter: A possible cause of hypertension, Drugs, 25, 2, pp. 64-68, (1983)

[9]

Egan B., Panis R., Hinderliter A., Et al., Mechanism of increased alpha adrenergic vasoconstriction in human essential hypertension, J Clin Invest, 80, pp. 812-817, (1987)

[10]

Peuler J.D., Johnson G.A., Simultaneous single radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine, Life Sci, 21, pp. 625-636, (1977)

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