ENDOTHELIN-1-LIKE IMMUNOREACTIVITY IN HUMAN URINE

被引：57

作者：

ANDO, K

HIRATA, Y

TAKEI, Y

KAWAKAMI, M

MARUMO, F

机构：

[1] TOKYO MED & DENT UNIV,DEPT INTERNAL MED 2,DIV ENDOCRINE,YUSHIMA 1-5-45,BUNKYO KU,TOKYO 113,JAPAN

[2] KITASATO UNIV,SCH MED,DEPT PHYSIOL,KITASATO BIOCHEM LABS,SAGAMIHARA,KANAGAWA 228,JAPAN

[3] KITASATO UNIV,SCH MED,DEPT MOLEC BIOL,SAGAMIHARA,KANAGAWA 228,JAPAN

来源：

NEPHRON | 1991年 / 57卷 / 01期

关键词：

D O I：

10.1159/000186212

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

By using a radioimmunoassay specific for endothelin-1 (ET-1), we studied whether ET-1-like immunoreactivity (LI) is present in human urine. Significant amounts of ET-1-LI were present in human urine, and the daily urinary excretion of ET-1-LI in 30 normal subjects was 67.6 ± 35.5 ng/day. The mean urinary excretion of ET-1-LI determined in spot urine was 82.8 ± 38.2 pg/mg creatinine (n = 30), while the mean plasma concentrations of ET-1-LI in the same individuals were 1.1 ± 0.5 pg/ml. There was no significant correlation between urinary ET-1-LI excretion and its plasma levels. Reverse-phase high-pressure liquid chromatography of human urine extract revealed a major ET-1-LI component coeluting with standard ET-1. The present study demonstrates the presence of ET-1-LI excreted in human urine, although its exact source and physiological significance in renal tissues remain to be determined.

引用

页码：36 / 39

页数：4

共 8 条

[1] PRESENCE OF IMMUNOREACTIVE ENDOTHELIN IN HUMAN-PLASMA [J].