DIACYLGLYCEROL FORMATION FROM PHOSPHATIDYLCHOLINE IN ANGIOTENSIN-II STIMULATED VASCULAR SMOOTH-MUSCLE CELLS

被引：17

作者：

KONDO, T ^{[1
]}

KONISHI, F ^{[1
]}

INUI, H ^{[1
]}

INAGAMI, T ^{[1
]}

机构：

[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)90466-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In cultured vascular smooth muscle cells (VSMC), angiotensin II (Ang II) induces a biphasic diacylglycerol (DAG) formation peaking at 15 sec and 5 min. Although it has been well established that the first peak is produced by the hydrolysis of inositol 4,5-bisphosphate (PIP2), the origin of the second DAG peak has never been examined in detail. In the present paper, we provide evidence that the second peak of DAG formation in Ang II-stimulated VSMC originates mainly from PC. © 1992.

引用

页码：1460 / 1465

页数：6

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