AMYLOID-BETA PROTEIN-INDUCED NEURONAL CELL-DEATH - NEUROTOXIC PROPERTIES OF AGGREGATED AMYLOID-BETA PROTEIN

被引：117

作者：

UEDA, K

FUKUI, Y

KAGEYAMA, H

机构：

[1] Division of Pharmacology, Shionogi Research Laboratories, Shionogi and Co. Ltd., Toyonaka, 561

来源：

BRAIN RESEARCH | 1994年 / 639卷 / 02期

关键词：

ALZHEIMERS DISEASE; AMYLOID-BETA PROTEIN; AGGREGATION; NEUROTOXIC; HIPPOCAMPAL CELL CULTURE; MTT ASSAY;

D O I：

10.1016/0006-8993(94)91736-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurotoxic effects of soluble and aggregated synthetic amyloid beta protein (AbetaP) have been investigated in rat primary cultures. Freshly solubilized beta(1-40) was neurotoxic not to immature, but to mature hippocampal neurons. On the other hand, aggregated beta(1-40) was neurotoxic to both. Neurotoxicity induced by aggregated beta(1-40) was 10-fold more potent than soluble beta(1-40) and was not prevented by substance P. The neurotoxicity of aggregated beta(1-40) to cultured neurons depended on the peptide concentration and the duration of exposure to, it. Cerebral cortical and hippocampal neurons were significantly susceptible to aggregated beta(1-40) than cerebellar granular cells, and cultured astrocytes were not vulnerable to aggregated beta(1-40) even at high concentrations.

引用

页码：240 / 244

页数：5

共 23 条

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