TRANS-MEMBRANE TRANSLOCATION OF A MYRISTYLATED PROTEIN AMINO-TERMINUS

被引:9
作者
GALLINA, A [1 ]
MILANESI, G [1 ]
机构
[1] CNR, IST GENET BIOCHIM & EVOLUZIONIST, VIA ABBIATEGRASSO 207, I-27100 PAVIA, ITALY
关键词
D O I
10.1006/bbrc.1993.2093
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hepatitis B virus surface protein variants are described, capable of translocating to the lumenal side of the endoplasmic reticulum membrane their myristylated N-termini, as revealed by the contestual modification of N-terminal, N-linked glycosylation sites. To our knowledge, this is the first example of transmembrane translocation of a preformed protein acyl adduct. The possible significance of this event for hepatitis B virus biology is discussed. © 1993 Academic Press, Inc.
引用
收藏
页码:637 / 642
页数:6
相关论文
共 14 条
[1]   HEPATITIS-B VIRUS LARGE SURFACE PROTEIN IS NOT SECRETED BUT IS IMMUNOGENIC WHEN SELECTIVELY EXPRESSED BY RECOMBINANT VACCINIA VIRUS [J].
CHENG, KC ;
SMITH, GL ;
MOSS, B .
JOURNAL OF VIROLOGY, 1986, 60 (02) :337-344
[2]   MYRISTYLATION OF PICORNAVIRUS CAPSID PROTEIN VP4 AND ITS STRUCTURAL SIGNIFICANCE [J].
CHOW, M ;
NEWMAN, JFE ;
FILMAN, D ;
HOGLE, JM ;
ROWLANDS, DJ ;
BROWN, F .
NATURE, 1987, 327 (6122) :482-486
[3]   CLONING, EXPRESSION, ISOLATION AND CHARACTERIZATION OF THE PRE-S DOMAINS OF HEPATITIS-B SURFACE-ANTIGEN, DEVOID OF THE S-PROTEIN [J].
DELOS, S ;
VILLAR, MT ;
HU, PS ;
PETERSON, DL .
BIOCHEMICAL JOURNAL, 1991, 276 :411-416
[4]   THE N-TERMINAL (PRE-S2) DOMAIN OF A HEPATITIS B-VIRUS SURFACE GLYCOPROTEIN IS TRANSLOCATED ACROSS MEMBRANES BY DOWNSTREAM SIGNAL SEQUENCES [J].
EBLE, BE ;
LINGAPPA, VR ;
GANEM, D .
JOURNAL OF VIROLOGY, 1990, 64 (03) :1414-1419
[5]   TRANSLATIONAL MODULATION IN HEPATITIS-B VIRUS PRES-S OPEN READING FRAME EXPRESSION [J].
GALLINA, A ;
DEKONING, A ;
ROSSI, F ;
CALOGERO, R ;
MANSERVIGI, R ;
MILANESI, G .
JOURNAL OF GENERAL VIROLOGY, 1992, 73 :139-148
[6]  
GANEM D, 1991, CURR TOP MICROBIOL, V168, P61
[7]   NOVEL N-TERMINAL AMINO-ACID SEQUENCE REQUIRED FOR RETENTION OF A HEPATITIS-B VIRUS GLYCOPROTEIN IN THE ENDOPLASMIC-RETICULUM [J].
KUROKI, K ;
RUSSNAK, R ;
GANEM, D .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (10) :4459-4466
[8]   MYRISTYLATION OF A DUCK HEPATITIS-B VIRUS ENVELOPE PROTEIN IS ESSENTIAL FOR INFECTIVITY BUT NOT FOR VIRUS ASSEMBLY [J].
MACRAE, DR ;
BRUSS, V ;
GANEM, D .
VIROLOGY, 1991, 181 (01) :359-363
[9]   CONTROL OF PROTEIN EXIT FROM THE ENDOPLASMIC-RETICULUM [J].
PELHAM, HRB .
ANNUAL REVIEW OF CELL BIOLOGY, 1989, 5 :1-23
[10]   INHIBITION OF SECRETION OF HEPATITIS-B SURFACE-ANTIGEN BY A RELATED PRESURFACE POLYPEPTIDE [J].
PERSING, DH ;
VARMUS, HE ;
GANEM, D .
SCIENCE, 1986, 234 (4782) :1388-1391