SYNTHESIS OF PEPTIDES CONTAINING THE BETA-SUBSTITUTED AMINOETHANE SULFINAMIDE OR SULFONAMIDE TRANSITION-STATE ISOSTERE DERIVED FROM AMINO-ACIDS

被引：47

作者：

MOREE, WJ ^{[1
]}

VANDERMAREL, GA ^{[1
]}

LISKAMP, RMJ ^{[1
]}

机构：

[1] LEIDEN UNIV, GORLAEUS LABS, POB 9502, 2300 RA LEIDEN, NETHERLANDS

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(00)60981-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alpha-amino acids can be converted to homochiral beta-substituted aminoethane sulfinamide or sulfonamide transition-state isosteres, which can be incorporated into peptides. These transition-state analogues e.g. the sulfonamide isostere of Phe-Phe will be used for the generation of catalytic antibodies as well as for the development of protease inhibitors.

引用

页码：6389 / 6392

页数：4

共 31 条

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