SYNTHESIS OF MYRISTIC ACID ANALOGS WITH ANTI-HIV ACTIVITY THAT MAY BE RESISTANT TO METABOLIC PROCESSING BY BETA-OXIDATION

被引：11

作者：

DEVADAS, B

KISHORE, NS

ADAMS, SP

GORDON, JI

机构：

[1] G D SEARLE,DEPT MOLEC & CELL BIOL,ST LOUIS,MO 63198

[2] WASHINGTON UNIV,SCH MED,DEPT MOLEC BIOL & PHARMACOL,ST LOUIS,MO 63110

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81274-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel classes of oxatetradecanoic acid analogs 10,11,13,16, and 21 were synthesized as alternative substrates for myristoylCoA:protein N-myristoyltransferase. These compounds inhibit replication of human immunodeficiency virus I (HIV-I) in acutely infected CD4-positive human T lymphocyte cell lines. The antiviral activity and potential metabolic stability of these compounds may make attractive therapeutic agents.

引用

收藏

页码：779 / 784

页数：6

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