SYNTHESIS OF PHOSPHATIDYLETHANOL - A POTENTIAL MARKER FOR ADULT MALES AT RISK FOR ALCOHOLISM

被引：60

作者：

MUELLER, GC ^{[1
]}

FLEMING, MF ^{[1
]}

LEMAHIEU, MA ^{[1
]}

LYBRAND, GS ^{[1
]}

BARRY, KJ ^{[1
]}

机构：

[1] UNIV WISCONSIN, SCH MED, DEPT FAMILY MED, MADISON, WI 53715 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1988年 / 85卷 / 24期

关键词：

D O I：

10.1073/pnas.85.24.9778

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phosphatidylethanol, whose synthesis is catalyzed by a phospholipase D in a transphosphatidylation reaction, is a unique metabolite of ethanol. Phorbol 12-tetradecanoate 13-acetate, a tumor-promoting phorbol ester and stimulator of protein kinase C, activities this enzyme in pheripheral blood lymphocytes. This system has been developed into an assay for measuring the potential of this pathway in human subjects. A pilot study of phosphatidylethanol synthesis in lymphocytes of adult males who have both an alcohol dependency and a family history of alcoholism has revealed that the average potential for phosphatidylethanol synthesis in this population is significantly elevated over that of control subjects.

引用

页码：9778 / 9782

页数：5

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