PHARMACOGENETICS OF ACUTE AZATHIOPRINE TOXICITY - RELATIONSHIP TO THIOPURINE METHYLTRANSFERASE GENETIC-POLYMORPHISM

被引：475

作者：

LENNARD, L ^{[1
]}

VANLOON, JA ^{[1
]}

WEINSHILBOUM, RM ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DEPT PHARMACOL,CLIN PHARMACOL UNIT,ROCHESTER,MN 55905

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1989年 / 46卷 / 02期

关键词：

D O I：

10.1038/clpt.1989.119

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：149 / 154

页数：6

共 23 条

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[7] KVIEN TK, 1986, J RHEUMATOL, V13, P118
[8] SEVERE MEGALOBLASTIC-ANEMIA ASSOCIATED WITH ABNORMAL AZATHIOPRINE METABOLISM
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[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 17 (02) : 171 - 172
[9] THIOPURINE PHARMACOGENETICS IN LEUKEMIA - CORRELATION OF ERYTHROCYTE THIOPURINE METHYLTRANSFERASE ACTIVITY AND 6-THIOGUANINE NUCLEOTIDE CONCENTRATIONS
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[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 41 (01) : 18 - 25
[10] AZATHIOPRINE METABOLISM IN KIDNEY-TRANSPLANT RECIPIENTS
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[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 18 (05) : 693 - 700

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