LOCAL-ANESTHESIA IN PEDIATRIC-PATIENTS - TOPICAL TAC VERSUS LIDOCAINE

被引:33
作者
ANDERSON, AB
COLECCHI, C
BARONOSKI, R
DEWITT, TG
机构
[1] Division of General and Community Pediatrics, Pediatric Emergency Services, Department of Pharmacy, Worcester
关键词
pediatric patients; TAC;
D O I
10.1016/S0196-0644(05)82182-1
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Lacerations requiring sutures are a common surgical emergency in children. Traditional anesthesia prior to suturing has been intradermal lidocaine. TAC (0.5% tetracaine, 1:2,000 adrenalin, 11.8% cocaine) is a topically applied anesthetic. A randomized, placebo-controlled, double-blind clinical study was conducted to test the hypothesis that topical TAC and intradermal lidocaine are equally efficacious with respect to patient compliance with the suturing process, ie, anesthetic application and placement of sutures, and development of wound complications. Patients less than 18 years old, with lacerations 5 cm or less in length, located in well vascularized, nonmucous membrane areas were included. Patients were entered into the intradermal or topical groups; the intradermal group received lidocaine and the topical group was randomized to receive either TAC or placebo. One hundred fifty-one patients were enrolled in the study. There was no significant difference in the rates of successful initial anesthesia with TAC (89%) and lidocaine (79%). TAC was significantly better (P < .002) with regard to patient compliance with the suturing process than lidocaine or placebo. Seventeen percent of patients who received placebo had initial anesthesia. These results suggest that TAC, when applied correctly, may be the preferred anesthetic for laceration repair in children. © 1990 American College of Emergency Physicians.
引用
收藏
页码:519 / 522
页数:4
相关论文
共 13 条
[1]  
Sibert, Maddocks, Brown, Childhood accidents, Arch Dis Child, 56, pp. 225-234, (1981)
[2]  
Adriani, Zepernick, Clinical effectiveness of drugs used for topical anaesthesia, JAMA, 188, pp. 711-716, (1964)
[3]  
Barker, Rodheaver, Edgerton, Et al., Damage to tissue defenses by a topical anesthetic agent, Ann Emerg Med, 11, pp. 307-310, (1982)
[4]  
Lyman, McCabe, Improving the effectiveness of TAC application, Ann Emerg Med, 13, (1984)
[5]  
Manjo, The Healing Hand, Man and Wound, (1977)
[6]  
Pryor, Kilpatrick, Opp, Local anesthesia in minor lacerations: Topical TAC vs lidocaine infiltration, Ann Emerg Med, 9, pp. 568-571, (1980)
[7]  
White, Iserson, The attack on TAC, Ann Emerg Med, 13, pp. 214-215, (1984)
[8]  
White, Iserson, Criss, Topical anesthesia for laceration repair: Tetracaine vs TAC (tetracaine, adrenalin, cocaine), Am J Emerg Med, 4, pp. 319-322, (1986)
[9]  
Bonadio, Wagner, Efficacy of TAC topical anaesthetic for repair of pediatric lacerations, Am J Dis Child, 142, pp. 203-205, (1988)
[10]  
Beecher, The powerful placebo, JAMA, 159, pp. 1602-1606, (1955)