ENANTIOSELECTIVE SYNTHESIS USING CHIRAL HETEROGENEOUS CATALYSTS

The application of solid chiral catalysts for the enantioselective synthesis of chiral molecules is reviewed. An attempt has been made to discuss critically the scope and limitations of these catalytic systems and their value for the synthetic organic chemist. The different catalytic systems described in the literature are tabulated and the enantioselectivities observed for different reactions are summarized according to the functional group which is transformed. Conclusions concerning synthetic and commercial-scale applications and some ideas on the mode of action of chiral solid catalysts are presented.