THE CALCIUM-ANTAGONIST ISRADIPINE AND ITS EFFECT ON BLOOD-PRESSURE RELATED TO PLASMA-RENIN ACTIVITY

被引：5

作者：

CARR, AA

PRISANT, LM

机构：

[1] The Section of Hypertension, Department of Medicine, Medical College of Georgia, Augusta

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 05期

关键词：

Calcium antagonist; Catecholamines; Essential hypertension; Isradipine; Plasma renin activity;

D O I：

10.1093/ajh/3.5.354

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

This study was designed to test the hypothesis that peripheral vein plasma renin activity is a determinant of the magnitude of the hypotensive effect of the calcium antagonist Isradipine when given to mild to moderately severe essential hypertensives. There was significant relationship between plasma renin activity and blood pressure reduction by Isradipine. The lower the plasma renin activity the greater the blood pressure reduction. Both plasma volume and initial diastolic blood pressure level were not determinants. Thus, low peripheral vein plasma renin activity is a determinant (marker) of the hypotensive effect of Isradipine in mild to moderately severe uncomplicated essential hypertensives. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：354 / 359

页数：6

共 30 条

[1]

Haber E., Koener T., Page L.B., Kliman B., Purnode A., Application of radioimmunoassay for angiotensin I to physiologic measurements of plasma renin activity in normal human subjects, J Clin Endocrinol, 23, pp. 1349-1355, (1969)

[2]

Skowsky W.R., Fisher D.A., The use of thyroglobulin to induce antigenicity to small molecules, J Lab Clin Med, 80, pp. 134-144, (1972)

[3]

Nielsen M.D., Jorgensen M., Giese J., 125I-labelling of angiotensin I and II, Acta Endocrinol, 67, pp. 104-116, (1971)

[4]

Davis G.C., Kissinger P.J., Shoup R.E., Urine and plasma norepinephrine, epinephrine and dopamine by high pressure reverse phase liquid chromatography and electrochemical detection, Anal Chem, 53, pp. 156-159, (1981)

[5]

Pisano J.J., A simple analysis for normetanephrines and metanephrine in urine, Clin Chim Acta, 5, pp. 406-414, (1960)

[6]

Pisano J.J., Crout J.R., Abraham D., Determination of 3 methoxy, 4-hydroxymandelic acid in urine, Clin Chim Acta, 7, pp. 285-291, (1962)

[7]

Agabiti Rosei E., Mueesan M.L., Romanelli G., Et al., Similarities and differences in antihypertensive effect of tow calcium antagonist drugs, varapamil and nifedipine, J Am Coll Cardiol, 7, pp. 916-924, (1986)

[8]

Marone C., Luisoli S., Bomio F., Et al., Pressor factors and cardiovascular pressor responsiveness after short-term antihypertensive therapy with the calcium antagonist nifedipine alone or combined with a diuretic, J Clin Hypertens, 2, pp. S449-S452, (1984)

[9]

Muiesan G., Agabiti Rosei E., Castellano M., Et al., Antihypertensive and humoral effects of verapamil and nifedipine in essential hypertention, J Cardiovasc Pharmacol, 4, pp. S325-S329, (1982)

[10]

Stadler P., Leonard L., Riesen W., Et al., Cardiovascular effects of verapamil in essential hypertension, Clin Pharmacol Ther, 42, pp. 485-492, (1987)

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