DEUTERATED TECHNETIUM-ISONITRILE COMPLEXES WITH CARDIAC AFFINITY

被引：1

作者：

WENZEL, M

机构：

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1991年 / 29卷 / 03期

关键词：

DEUTERIUM; ISONITRILES; MYOCARD-AFFINITY;

D O I：

10.1002/jlcr.2580290304

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

t-Butylisonitril (TBI) and Methoxy-isobutyl-isonitril (MIBI) were labelled with deuterium leading to TBI-d2 and MIBI-d2 or MIBI-d5. After labelling with 99mTc the organ-distribution in mice and rats was studied. The deuterated isonitriles showed only a small increase in myocard-affinity but a significant decrease in blood concentration, so more favourable ratios heart/blood were reached.

引用

页码：265 / 271

页数：7

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