SEROTONIN RESPONSE IN SWEET-FOOD CRAVING ALZHEIMERS-DISEASE SUBJECTS

被引：8

作者：

COOPER, JK

MUNGAS, D

机构：

[1] Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California

[2] National Institute on Aging, Bethesda, Maryland, 20892, Bldg. 31

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1992年 / 4卷 / 02期

关键词：

ALZHEIMERS DISEASE; DIETARY BEHAVIOR; FENFLURAMINE; PROLACTIN; SEROTONIN;

D O I：

10.1007/BF03324086

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Abnormal sweet-food craving may occur in subjects with Alzheimer's disease. This behavior may be due to abnormalities in the brain serotonin system. Fenfluramine stimulates the brain serotonin neurosystem, producing an increase in systemic prolactin. Using the fenfluramine stimulation test, brain serotonin system response was evaluated in 12 subjects with probable Alzheimer's disease. The subjects' caregivers completed questionnaires concerning subject food preferences and behaviors. Alzheimer's disease subjects with sweet-food craving were found to. have a significantly higher response to fenfluramine than non sweet-food craving subjects. This preliminary study is limited by small sample size. Allowing for assumptions concerning central nervous system regulatory processes, the data suggest a possible role for the serotonin system in sweet-food craving in Alzheimer's disease.

引用

页码：165 / 169

页数：5

共 34 条

[31]

Mann J.J., Arango V., Marzuk P.M., Theccanat S., Reis D.J., Evidence for the 5 HT hypothesis of suicide. A review of post-mortem studies, Br. J. Psychiatry, 155, 8, pp. 7-14, (1989)

[32]

Dinan T.G., Yatham L.N., Barry S., Chua A., Keeling W.N., Serotonin supersensitivity: the pathophysiologic basis of non-ulcer dyspepsia, Scand. J. Gastroenterol., 25, pp. 541-544, (1990)

[33]

Plasma H.V.A., neuroleptics, and dopaminergic plasticity. (Editorial), Biol. Psychiatry, 25, pp. 1-3, (1989)

[34]

Schneider L.S., Pollock V.E., Lyness M.A., A meta-analysis of controlled trials of neuroleptic treatment in dementia, J. Am. Geriatr. Soc., 38, pp. 553-563, (1990)

← 1 2 3 4 →