SYSTEMIC ADMINISTRATION OF BACLOFEN INHIBITS WATER-INTAKE IN RATS

被引：20

作者：

EBENEZER, IS

HOUSTON, AJ

CROOK, TJ

机构：

[1] Neuropharmacology Research Group, School of Pharmacy and Biomedical Science, Portsmouth Polytechnic, Portsmouth

来源：

GENERAL PHARMACOLOGY | 1992年 / 23卷 / 03期

关键词：

D O I：

10.1016/0306-3623(92)90097-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The present experiments were carried out to investigate the effects of systemic administration of baclofen on water intake in rats. 2. Baclofen (1, 2 and 4 mg/kg, s.c.) inhibited water intake in 16 hr water-deprived rats in a dose-related manner, with maximal effects occurring during the first 30 min after administration. 3. Baclofen (0.25 and 2 mg/kg, s.c.) had no effects on water intake in non-deprived rats. 4. Baclofen (2 mg/kg) inhibited water intake elicited by i.p. injection of hypertonic NaCl in rats. 5, Baclofen (1 mg/kg) did not produce taste aversion in a taste aversion experiment. This indicates that the effects of baclofen on water intake is not due to an aversive effect of the drug.

引用

页码：375 / 379

页数：5

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