STUDY OF THE K' OR LOG K'-LOG P-OW CORRELATION FOR A GROUP OF BENZENE-DERIVATIVES AND POLYCYCLIC AROMATIC-HYDROCARBONS IN MICELLAR LIQUID-CHROMATOGRAPHY WITH A C-8 COLUMN

The correlation between the capacity factor (k') or its logarithm (log k') and the logarithm of the octanol-water partition coefficient (log P-ow) for a group of 23 organic compounds (eleven benzene derivatives and twelve polycyclic aromatic hydrocarbons) was studied. The hydrophobicity range of the compounds chosen to study these correlations seems to be an important factor. In fact, the average r(2) values for 69 mobile phases of different composition and the 23-compound group is better for k'-log P-ow than for the log k'-log P-ow correlation. However, the average r(2) values for 84 different mobile phases proved to be better in the log k'-log P-ow correlation for the fifteen benzene and naphthalene derivatives group and similar in k'-log P-ow and log k'-log P-ow correlations for the ten monosubstituted benzene derivatives group.