CELL ABNORMALITIES ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED SQUAMOUS INTRAEPITHELIAL CERVICAL LESIONS - MULTIVARIATE DATA-ANALYSIS

被引:10
作者
MAYELO, V
GARAUD, P
RENJARD, L
DIANOUX, L
LANSAC, J
LHUINTRE, Y
COURSAGET, P
ANTHONIOZ, P
机构
[1] CHR UNIV BRETONNEAU, ANAT PATHOL LAB, F-37000 TOURS, FRANCE
[2] HOP ST LOUIS, CNRS, UNITE PROPRE RECH, PARIS, FRANCE
[3] ASSOC PAUL METADIER, TOURS, FRANCE
[4] CHRU, DEPT GYNECOL OBSTET & REPROD HUMAINE, TOURS, FRANCE
[5] FAC PHARM TOURS, INST VIROL, TOURS, FRANCE
关键词
CYTOLOGY; HUMAN PAPILLOMAVIRUS; MULTIPLE CORRESPONDENCE ANALYSIS; POLYMERASE CHAIN REACTION; SQUAMOUS INTRAEPITHELIAL LESIONS; STATISTICS;
D O I
10.1093/ajcp/101.1.13
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
One hundred ninety-six cervical scrapings sere obtained for simultaneous research of cell abnormalities in Papanicolaou smears and detection of genital human papillomavirus (HPV) genotypes by polymerase chain reaction in extracted DNA from each clinical sample. The samples described by six discriminant cytologic parameters, and a synthetic HPV-presence/absence parameter provided an efficient matrix for multiple correspondence analysis. This statistical analysis displayed a plurality of HPV-related cell abnormalities in squamous intraepithelial lesions, and a high correspondence between HPV infection and the presence of multinucleated squamous cells, morphologically trans-formed keratinocytes (dyskaryotic cells), koilocytes, and cellular changes related to epithelial maturation. Because of the low proportion of detectable koilocytes in the HPV-infected scrapings, the authors also inferred that cellular changes related to epithelial maturation and morphologically transformed keratinocytes are the most accurate and efficient cell abnormalities, in terms of frequency and correlation, for cytodiagnosis of HPV-induced or associated squamous intraepithelial cervical lesions.
引用
收藏
页码:13 / 18
页数:6
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