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DECREASED REACTIVITY TO ANXIOLYTICS CAUSED BY EARLY PROTEIN-MALNUTRITION IN RATS
被引:27
作者
:
ALMEIDA, SS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SAO PAULO,FAC FILOSOFIA CIENCIAS & LETRAS RIBEIRAO PRETO,PSICOBIOL LAB,BR-14049 RIBEIRAO PRETO,SP,BRAZIL
UNIV SAO PAULO,FAC FILOSOFIA CIENCIAS & LETRAS RIBEIRAO PRETO,PSICOBIOL LAB,BR-14049 RIBEIRAO PRETO,SP,BRAZIL
ALMEIDA, SS
[
1
]
DEOLIVEIRA, LM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SAO PAULO,FAC FILOSOFIA CIENCIAS & LETRAS RIBEIRAO PRETO,PSICOBIOL LAB,BR-14049 RIBEIRAO PRETO,SP,BRAZIL
UNIV SAO PAULO,FAC FILOSOFIA CIENCIAS & LETRAS RIBEIRAO PRETO,PSICOBIOL LAB,BR-14049 RIBEIRAO PRETO,SP,BRAZIL
DEOLIVEIRA, LM
[
1
]
GRAEFF, FG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SAO PAULO,FAC FILOSOFIA CIENCIAS & LETRAS RIBEIRAO PRETO,PSICOBIOL LAB,BR-14049 RIBEIRAO PRETO,SP,BRAZIL
UNIV SAO PAULO,FAC FILOSOFIA CIENCIAS & LETRAS RIBEIRAO PRETO,PSICOBIOL LAB,BR-14049 RIBEIRAO PRETO,SP,BRAZIL
GRAEFF, FG
[
1
]
机构
:
[1]
UNIV SAO PAULO,FAC FILOSOFIA CIENCIAS & LETRAS RIBEIRAO PRETO,PSICOBIOL LAB,BR-14049 RIBEIRAO PRETO,SP,BRAZIL
来源
:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
|
1990年
/ 36卷
/ 04期
关键词
:
Diazepam;
Early protein malnutrition;
Hypertonic saline intake;
Ipsapirone;
D O I
:
10.1016/0091-3057(90)90113-V
中图分类号
:
B84 [心理学];
C [社会科学总论];
Q98 [人类学];
学科分类号
:
03 ;
0303 ;
030303 ;
04 ;
0402 ;
摘要
:
In order to investigate whether early malnutrition causes lasting changes in the reactivity to anxiolytic drugs, rat dams during lactation (21 days) and pups after weaning until the 49th day of life were fed on 8% casein diet (M rats), while their well-nourished controls received 25% casein (W rats). From day 50 on all animals ate the same balanced diet. Experiments started on the 91st day. Rats deprived for 22 hours drank water containing either 1.8% or 2.7% sodium chloride for 30 min in a test chamber, total intake being measured. Dose-effect curves for diazepam (0.5-5.0 mg/kg, IP), as well as for the nonbezodiazepine anxiolytics ipsapirone (0.5-5.0 mg/kg), ritanserin (0.05-1.0 mg/kg) and isamoltane (2.5-20.0 mg/kg) were determined in M as well as in W rats. Diazepam and ipsapirone dose-dependently released drinking suppressed by either salt concentration in W rats, but caused little or no effect in M rats. Ritanserin and isamoltane were ineffective in both groups. These and previously reported results show that early protein malnutrition markedly reduces anticonflict effects of anxiolytics, indicating long-lasting impairment of neuronal systems underlying emotional behavior. © 1990.
引用
收藏
页码:997 / 1000
页数:4
相关论文
共 25 条
[1]
PROTEIN-DEPRIVATION AND THE BRAIN - EFFECT ON ENZYMES AND FREE AMINO-ACIDS RELATED TO GLUTAMATE METABOLISM IN RATS
AGARWAL, KN
论文数:
0
引用数:
0
h-index:
0
AGARWAL, KN
PRASAD, C
论文数:
0
引用数:
0
h-index:
0
PRASAD, C
TANEJA, V
论文数:
0
引用数:
0
h-index:
0
TANEJA, V
[J].
ANNALS OF NUTRITION AND METABOLISM,
1981,
25
(04)
: 228
-
233
[2]
ALMEIDA SS, 1988, BRAZ J MED BIOL RES, V21, P1033
[3]
POSTNATAL NUTRITIONAL DEPRIVATIONS AS DETERMINANTS OF ADULT RAT BEHAVIOR TOWARD FOOD ITS CONSUMPTION AND UTILIZATION
BARNES, RH
论文数:
0
引用数:
0
h-index:
0
BARNES, RH
NEELY, CS
论文数:
0
引用数:
0
h-index:
0
NEELY, CS
KWONG, E
论文数:
0
引用数:
0
h-index:
0
KWONG, E
LABADAN, BA
论文数:
0
引用数:
0
h-index:
0
LABADAN, BA
FRANKOVA, S
论文数:
0
引用数:
0
h-index:
0
FRANKOVA, S
[J].
JOURNAL OF NUTRITION,
1968,
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[4]
OPERANT-BEHAVIOR AND REACTIVITY TO THE ANTICONFLICT EFFECT OF DIAZEPAM IN PERINATALLY UNDERNOURISHED RATS
BRIONI, JD
论文数:
0
引用数:
0
h-index:
0
机构:
NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5016 CORDOBA,ARGENTINA
NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5016 CORDOBA,ARGENTINA
BRIONI, JD
ORSINGHER, OA
论文数:
0
引用数:
0
h-index:
0
机构:
NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5016 CORDOBA,ARGENTINA
NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5016 CORDOBA,ARGENTINA
ORSINGHER, OA
[J].
PHYSIOLOGY & BEHAVIOR,
1988,
44
(02)
: 193
-
198
[5]
PERINATAL UNDERNUTRITION ALTERS HYPOTHERMIC RESPONSES TO DIFFERENT CENTRAL AGONISTS IN RECOVERED ADULT-RATS
BRIONI, JD
论文数:
0
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0
h-index:
0
BRIONI, JD
ORSINGHER, OA
论文数:
0
引用数:
0
h-index:
0
ORSINGHER, OA
[J].
NEUROPHARMACOLOGY,
1987,
26
(7A)
: 771
-
774
[6]
BEHAVIORAL AND 5-HT ANTAGONIST EFFECTS OF RITANSERIN - A PURE AND SELECTIVE ANTAGONIST OF LSD DISCRIMINATION IN RAT
COLPAERT, FC
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0
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0
COLPAERT, FC
MEERT, TF
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0
引用数:
0
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0
MEERT, TF
NIEMEGEERS, CJE
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0
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0
h-index:
0
NIEMEGEERS, CJE
JANSSEN, PAJ
论文数:
0
引用数:
0
h-index:
0
JANSSEN, PAJ
[J].
PSYCHOPHARMACOLOGY,
1985,
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54
[7]
BENZODIAZEPINES AND PUTATIVE 5-HT1A AGONISTS INCREASE HYPERTONIC SALINE CONSUMPTION IN REHYDRATING RATS
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COOPER, SJ
DESA, A
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0
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0
h-index:
0
DESA, A
[J].
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,
1987,
28
(02)
: 187
-
191
[8]
SPECIFIC EFFECT OF PUTATIVE 5-HT1A AGONISTS, 8-OH-DPAT AND GEPIRONE, TO INCREASE HYPERTONIC SALINE CONSUMPTION IN THE RAT - EVIDENCE AGAINST A GENERAL HYPERDIPSIC ACTION
COOPER, SJ
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COOPER, SJ
FRYER, MJ
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FRYER, MJ
NEILL, JC
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0
引用数:
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NEILL, JC
[J].
PHYSIOLOGY & BEHAVIOR,
1988,
43
(04)
: 533
-
537
[9]
MIDAZOLAM-INDUCED INCREASE IN NACL SOLUTION INGESTION - DIFFERENTIAL EFFECT OF THE BENZODIAZEPINE ANTAGONISTS RO-15-1788 AND CGS-8216
FALK, JL
论文数:
0
引用数:
0
h-index:
0
FALK, JL
TANG, M
论文数:
0
引用数:
0
h-index:
0
TANG, M
[J].
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,
1984,
21
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: 965
-
968
[10]
THE CONTRIBUTION OF BEHAVIORAL-STUDIES TO THE NEUROPHARMACOLOGY OF ANXIETY
FILE, SE
论文数:
0
引用数:
0
h-index:
0
FILE, SE
[J].
NEUROPHARMACOLOGY,
1987,
26
(7B)
: 877
-
886
←
1
2
3
→
共 25 条
[1]
PROTEIN-DEPRIVATION AND THE BRAIN - EFFECT ON ENZYMES AND FREE AMINO-ACIDS RELATED TO GLUTAMATE METABOLISM IN RATS
AGARWAL, KN
论文数:
0
引用数:
0
h-index:
0
AGARWAL, KN
PRASAD, C
论文数:
0
引用数:
0
h-index:
0
PRASAD, C
TANEJA, V
论文数:
0
引用数:
0
h-index:
0
TANEJA, V
[J].
ANNALS OF NUTRITION AND METABOLISM,
1981,
25
(04)
: 228
-
233
[2]
ALMEIDA SS, 1988, BRAZ J MED BIOL RES, V21, P1033
[3]
POSTNATAL NUTRITIONAL DEPRIVATIONS AS DETERMINANTS OF ADULT RAT BEHAVIOR TOWARD FOOD ITS CONSUMPTION AND UTILIZATION
BARNES, RH
论文数:
0
引用数:
0
h-index:
0
BARNES, RH
NEELY, CS
论文数:
0
引用数:
0
h-index:
0
NEELY, CS
KWONG, E
论文数:
0
引用数:
0
h-index:
0
KWONG, E
LABADAN, BA
论文数:
0
引用数:
0
h-index:
0
LABADAN, BA
FRANKOVA, S
论文数:
0
引用数:
0
h-index:
0
FRANKOVA, S
[J].
JOURNAL OF NUTRITION,
1968,
96
(04)
: 467
-
&
[4]
OPERANT-BEHAVIOR AND REACTIVITY TO THE ANTICONFLICT EFFECT OF DIAZEPAM IN PERINATALLY UNDERNOURISHED RATS
BRIONI, JD
论文数:
0
引用数:
0
h-index:
0
机构:
NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5016 CORDOBA,ARGENTINA
NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5016 CORDOBA,ARGENTINA
BRIONI, JD
ORSINGHER, OA
论文数:
0
引用数:
0
h-index:
0
机构:
NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5016 CORDOBA,ARGENTINA
NATL UNIV CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5016 CORDOBA,ARGENTINA
ORSINGHER, OA
[J].
PHYSIOLOGY & BEHAVIOR,
1988,
44
(02)
: 193
-
198
[5]
PERINATAL UNDERNUTRITION ALTERS HYPOTHERMIC RESPONSES TO DIFFERENT CENTRAL AGONISTS IN RECOVERED ADULT-RATS
BRIONI, JD
论文数:
0
引用数:
0
h-index:
0
BRIONI, JD
ORSINGHER, OA
论文数:
0
引用数:
0
h-index:
0
ORSINGHER, OA
[J].
NEUROPHARMACOLOGY,
1987,
26
(7A)
: 771
-
774
[6]
BEHAVIORAL AND 5-HT ANTAGONIST EFFECTS OF RITANSERIN - A PURE AND SELECTIVE ANTAGONIST OF LSD DISCRIMINATION IN RAT
COLPAERT, FC
论文数:
0
引用数:
0
h-index:
0
COLPAERT, FC
MEERT, TF
论文数:
0
引用数:
0
h-index:
0
MEERT, TF
NIEMEGEERS, CJE
论文数:
0
引用数:
0
h-index:
0
NIEMEGEERS, CJE
JANSSEN, PAJ
论文数:
0
引用数:
0
h-index:
0
JANSSEN, PAJ
[J].
PSYCHOPHARMACOLOGY,
1985,
86
(1-2)
: 45
-
54
[7]
BENZODIAZEPINES AND PUTATIVE 5-HT1A AGONISTS INCREASE HYPERTONIC SALINE CONSUMPTION IN REHYDRATING RATS
COOPER, SJ
论文数:
0
引用数:
0
h-index:
0
COOPER, SJ
DESA, A
论文数:
0
引用数:
0
h-index:
0
DESA, A
[J].
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,
1987,
28
(02)
: 187
-
191
[8]
SPECIFIC EFFECT OF PUTATIVE 5-HT1A AGONISTS, 8-OH-DPAT AND GEPIRONE, TO INCREASE HYPERTONIC SALINE CONSUMPTION IN THE RAT - EVIDENCE AGAINST A GENERAL HYPERDIPSIC ACTION
COOPER, SJ
论文数:
0
引用数:
0
h-index:
0
COOPER, SJ
FRYER, MJ
论文数:
0
引用数:
0
h-index:
0
FRYER, MJ
NEILL, JC
论文数:
0
引用数:
0
h-index:
0
NEILL, JC
[J].
PHYSIOLOGY & BEHAVIOR,
1988,
43
(04)
: 533
-
537
[9]
MIDAZOLAM-INDUCED INCREASE IN NACL SOLUTION INGESTION - DIFFERENTIAL EFFECT OF THE BENZODIAZEPINE ANTAGONISTS RO-15-1788 AND CGS-8216
FALK, JL
论文数:
0
引用数:
0
h-index:
0
FALK, JL
TANG, M
论文数:
0
引用数:
0
h-index:
0
TANG, M
[J].
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,
1984,
21
(06)
: 965
-
968
[10]
THE CONTRIBUTION OF BEHAVIORAL-STUDIES TO THE NEUROPHARMACOLOGY OF ANXIETY
FILE, SE
论文数:
0
引用数:
0
h-index:
0
FILE, SE
[J].
NEUROPHARMACOLOGY,
1987,
26
(7B)
: 877
-
886
←
1
2
3
→