EFFECT OF CHRONIC HALOTHANE EXPOSURE ON LIPID-PEROXIDATION, OSMOTIC FRAGILITY AND MORPHOLOGY OF RAT ERYTHROCYTES

被引：8

作者：

TOKER, K

OZER, NK

YALCIN, AS

TUZUNER, S

GOGUS, FY

EMERK, K

机构：

[1] MARMARA UNIV,FAC MED,DEPT BIOCHEM,ISTANBUL,TURKEY

[2] MARMARA UNIV,FAC MED,DEPT ANESTHESIOL & REANIMAT,ISTANBUL,TURKEY

来源：

JOURNAL OF APPLIED TOXICOLOGY | 1990年 / 10卷 / 06期

关键词：

erythrocyte morphology; halothane; lipid peroxidation; osmotic fragility;

D O I：

10.1002/jat.2550100605

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Effect of chronic halothane exposure on hepatic and erythrocyte lipid peroxidation and erythrocyte osmotic fragility and morphology were determined in rats exposed to 0.4% halothane, 8 h per day for 40 days. Hepatic lipid peroxidation was increased in the halothane‐treated group compared to controls. Lipid peroxidation was not increased by halothane exposure in erythrocytes without hydrogen peroxide, but after peroxide supplementation lipid peroxidation increased more in the erythrocytes of halothane‐exposed rats than in control rats. We have observed significant morphological changes in erythrocytes from halothane‐treated rats. In addition, erythrocytes of halothane‐treated rats were more fragile in saline solutions compared to those of controls. Our results suggest that chronic halothane exposure is not only hepatotoxic but also affects erythrocyte membrane structure and stability. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：407 / 409

页数：3

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[2]

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[3]

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[4]

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