SUPERCRITICAL FLUID EXTRACTION OF ACTIVE COMPONENTS IN A DRUG FORMULATION

被引：33

作者：

MULCAHEY, LJ ^{[1
]}

TAYLOR, LT ^{[1
]}

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

来源：

ANALYTICAL CHEMISTRY | 1992年 / 64卷 / 09期

关键词：

D O I：

10.1021/ac00033a004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Sulfamethoxazole and trimethoprim have been extracted from a drug formulation, Septra Infusion, with pure supercritical carbon dioxide. Both direct extraction of the aqueous-based matrix and indirect extraction of the formulation immobilized onto Celite were studied. Exhaustive analytical extraction was achieved when active components were less than 1.0 mg. A number of co-extractants were found, but each was blind to the HPLC/UV assay.

引用

页码：981 / 984

页数：4