COMPARATIVE-STUDY OF THE STABILITY OF SAXITOXIN AND NEOSAXITOXIN IN ACIDIC SOLUTIONS AND LYOPHILIZED SAMPLES

被引：18

作者：

ALFONSO, A ^{[1
]}

LOUZAO, MC ^{[1
]}

VIEYTES, MR ^{[1
]}

BOTANA, LM ^{[1
]}

机构：

[1] FAC VET LUGO,DEPT FISIOL & FARMACOL,E-27002 LUGO,SPAIN

来源：

TOXICON | 1994年 / 32卷 / 12期

关键词：

D O I：

10.1016/0041-0101(94)90318-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Paralytic shellfish poison (PSP) has historically been a problem for the shellfish industry. In order to prevent the marketing of contaminated seafood products, governments have implemented monitoring programs where standards of toxins are necessary. The stability of these standard toxins is very important. In this paper we analysed the stability of saxitoxin (STX) and neosaxitoxin in acidic solution and lyophilized samples. Individual toxins were determined in each sample using a high-performance liquid chromatographic procedure employing postcolumn oxidation of the toxins to form fluorescent derivatives. Our results demonstrate that STX is very stable in solution samples and could be adopted as a reference standard. This toxin can be kept in dilute acidic solutions for 18 months without loss of potency. However, neosaxitoxin is unstable, possibly due to transformation

引用

页码：1593 / 1598

页数：6

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