REPRODUCIBILITY OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR INDUCED COUGH - A DOUBLE-BLIND RANDOMIZED STUDY

被引：13

作者：

CHARLON, V ^{[1
]}

DOLLOW, S ^{[1
]}

FIDEL, J ^{[1
]}

HOGLUND, C ^{[1
]}

HONKANEN, T ^{[1
]}

KOBRIN, I ^{[1
]}

MCEWAN, J ^{[1
]}

MCINNES, G ^{[1
]}

VISKOPER, JR ^{[1
]}

WOO, KS ^{[1
]}

机构：

[1] ROCHE PROD LTD, MAIDENHEAD SL6 1RD, BERKS, ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1995年 / 39卷 / 02期

关键词：

ANGIOTENSIN CONVERTING ENZYME INHIBITOR; COUGH; REPRODUCIBILITY; TRIGGER FACTORS; MULTIFACTORIAL;

D O I：

10.1111/j.1365-2125.1995.tb04418.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The reproducibility of angiotensin converting enzyme inhibitor induced cough was examined in a double-blind cross over study in patients previously shown to have exhibited this side effect. 2 Ninety-seven patients who had experienced angiotensin converting enzyme inhibitor cough within the last 2 years were challenged with enalapril 20 mg daily for 4 weeks to establish eligibility. Eighty-eight of 97 (91%) patients experienced a repeat of their cough symptoms. Sixty-four patients entered the double-blind part of the study where they were treated with enalapril 20 mg and a renin inhibitor for up to 4 weeks in random order. These periods were separated by a minimum 4 week placebo wash out. 3 Of 59 evaluable patients who received enalapril a second time, 37 (62.7%) experienced cough again. Of 62 patients on the renin inhibitor 16 (25.8%) experienced cough, however as it was not equi-efficacious to enalapril no valid comparison could be made. 4 Angiotensin converting enzyme inhibitor cough is not reproducible within patients, as other factors are involved in the aetiology. Objective testing with blinded assessment together with symptom reporting, would give a more accurate measure of the incidence, and mechanism of this side effect.

引用

页码：125 / 129

页数：5

共 21 条

[1] HYPERRESPONSIVENESS OF THE EXTRATHORACIC AIRWAY IN PATIENTS WITH CAPTOPRIL-INDUCED COUGH [J].