A Comparison of Category and Letter Fluency in Alzheimer's Disease and Huntington's Disease

被引：294

作者：

Monsch, Andreas U. ^{[1
,2
]}

Bondi, Mark W. ^{[1
,2
]}

Butters, Nelson ^{[1
,2
]}

Paulsen, Jane S. ^{[1
,2
]}

Salmon, David P. ^{[3
]}

Brugger, Peter ^{[1
,2
]}

Swenson, Michael R. ^{[3
]}

机构：

[1] Univ San Diego, Sch Med, Psychol Serv, San Diego Dept Vet Affairs Med Ctr, San Diego, CA 92110 USA

[2] Univ San Diego, Sch Med, Dept Psychiat, San Diego, CA 92110 USA

[3] Univ Calif San Diego, Sch Med, Dept Neurosci, San Diego, CA 92103 USA

来源：

NEUROPSYCHOLOGY | 1994年 / 8卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

D O I：

10.1037/0894-4105.8.1.25

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Forty-four patients with dementia of the Alzheimer type (DAT), 44 elderly normal control (ENC) Ss demographically matched to the DAT group, 42 patients with Huntington's disease (HD), and 42 middle-aged normal control (MNC) Ss demographically matched to the HD group were administered letter and category fluency tasks. DAT patients showed an overproportional impairment on category than on letter fluency tasks, whereas HD patients were equally impaired. Analyses based on receiver operating characteristic curves revealed that category fluency correctly classified significantly more DAT and ENC subjects than did letter fluency, whereas the two fluency tasks did not differ in this respect for HD and MNC subjects. Results suggest that HD patients' failures on fluency tasks are caused by impaired initiation/retrieval capacities. In contrast, DAT patients' greater category than letter fluency deficits are primarily due to a breakdown in the structure of semantic knowledge.

引用

页码：25 / 30

页数：6

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