STRUCTURE ACTIVITY RELATIONSHIP OF NSTX-3, SPIDER TOXIN OF NEPHILA-MACULATA

被引：20

作者：

TESHIMA, T

MATSUMOTO, T

WAKAMIYA, T

SHIBA, T

NAKAJIMA, T

KAWAI, N

机构：

[1] PROT RES FDN,INST PEPTIDE,MINO,OSAKA 562,JAPAN

[2] UNIV TOKYO,FAC PHARMACEUT SCI,DEPT ANALYT CHEM,BUNKYO KU,TOKYO 113,JAPAN

[3] TOKYO METROPOLITAN INST NEUROSCI,DEPT NEUROBIOL,FUCHU,TOKYO 183,JAPAN

来源：

TETRAHEDRON | 1990年 / 46卷 / 11期

关键词：

D O I：

10.1016/S0040-4020(01)90516-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a study on structure-activity relationship of spider toxin NSTX-3 obtained from venom of Nephila maculata, nine analogs or fragments of natural toxin were synthesized. Among them, des-Arg- NSTX-3 was found to be the minimum structure for blocking the excitatory transmission in the crustacean neuromuscular synapse. A positive charge of the arginine part was concluded to play the most important role for exhibition of the activity. © 1990.

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页码：3813 / 3818

页数：6

相关论文

共 11 条

[1] EFFECTS OF A SPIDER TOXIN ON THE GLUTAMINERGIC SYNAPSE OF LOBSTER MUSCLE [J].

ABE, T ;

KAWAI, N ;

MIWA, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 339 (JUN) :243-252

[2] STRUCTURES AND BIOLOGICAL-ACTIVITIES OF 3 SYNAPTIC ANTAGONISTS FROM ORB WEAVER SPIDER VENOM [J].

ADAMS, ME ;

CARNEY, RL ;

ENDERLIN, FE ;

FU, ET ;

JAREMA, MA ;

LI, JP ;

MILLER, CA ;

SCHOOLEY, DA ;

SHAPIRO, MJ ;

VENEMA, VJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (02) :678-683

[3] CHEMICAL CHARACTERIZATION OF SPIDER TOXIN, JS']JSTX AND NSTX [J].

ARAMAKI, Y ;

YASUHARA, T ;

HIGASHIJIMA, T ;

YOSHIOKA, M ;

MIWA, A ;

KAWAI, N ;

NAKAJIMA, T .

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1986, 62 (09) :359-362

[4]

GRISHIN EV, 1986, BIOORG KHIM+, V12, P1121

[5] SYNTHESIS OF SPIDER TOXIN (JS']JSTX-3) AND ITS ANALOGS [J].

HASHIMOTO, Y ;

ENDO, Y ;

SHUDO, K ;

ARAMAKI, Y ;

KAWAI, N ;

NAKAJIMA, T .

TETRAHEDRON LETTERS, 1987, 28 (30) :3511-3514

[6] SPIDER TOXINS - RECENT APPLICATIONS IN NEUROBIOLOGY [J].

JACKSON, H ;

PARKS, TN .

ANNUAL REVIEW OF NEUROSCIENCE, 1989, 12 :405-415

[7] SPIDER TOXINS AS TOOLS FOR DISSECTING ELEMENTS OF EXCITATORY AMINO-ACID TRANSMISSION [J].

JACKSON, H ;

USHERWOOD, PNR .

TRENDS IN NEUROSCIENCES, 1988, 11 (06) :278-283

[8] THE TOTAL SYNTHESIS OF ARGIOTOXIN-636, ARGIOTOXIN-659 AND ARGIOTOXIN-673 [J].

JASYS, VJ ;

KELBAUGH, PR ;

NASON, DM ;

PHILLIPS, D ;

SACCOMANO, NA ;

VOLKMANN, RA .

TETRAHEDRON LETTERS, 1988, 29 (48) :6223-6226

[9] THE TOTAL SYNTHESIS OF ARGIOPINE (ARGIOTOXIN-636) [J].

SHIH, TL ;

RUIZSANCHEZ, J ;

MROZIK, H .

TETRAHEDRON LETTERS, 1987, 28 (48) :6015-6018

[10] SYNTHESIS OF A NEW NEUROTOXIN NSTX-3 OF PAPUA-NEW-GUINEAN SPIDER [J].

TESHIMA, T ;

WAKAMIYA, T ;

ARAMAKI, Y ;

NAKAJIMA, T ;

KAWAI, N ;

SHIBA, T .

TETRAHEDRON LETTERS, 1987, 28 (30) :3509-3510