ALTERED MATURATION OF SMALL INTESTINAL FUNCTION IN THE ABSENCE OF INTRALUMINAL NUTRIENTS - RAPID NORMALIZATION WITH REFEEDING

被引:23
作者
CASTILLO, RO
FENG, JJ
STEVENSON, DK
KWONG, LK
机构
[1] Department of Pediatrics, Stanford University Med. Ctr., Stanford
关键词
INTESTINAL MATURATION; INTRALUMINAL NUTRIENTS; INTESTINAL FUNCTION; REFEEDING;
D O I
10.1093/ajcn/53.2.558
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The absence of intraluminal nutrients during weaning in rats was shown to result in altered intestinal growth and maturation. In this study intestinal length, mucosal weight, DNA, protein, and total disaccharidase activities were significantly lower in animals sustained by intravenous nutrients over the normal weaning age than were normally weaned controls but were greater than preweaning values. Absorptive capacity for sucrose (assessed by hydrogen-gas production) was diminished, directly linking incomplete maturation of sucrase to diminished intestinal function. To determine whether these alterations were permanent, rats previously deprived of intraluminal nutrients over the weaning period were refed. Eight days after refeeding, all variables except total lactase had attained values found in normally weaned age-matched controls, including absorptive capacity for sucrose. Although intestinal growth and maturation is abnormal in the absence of intraluminal nutrients during weaning, the abnormalities are not permanent and are rapidly corrected upon refeeding.
引用
收藏
页码:558 / 561
页数:4
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