LACK OF TOLERANCE OF HEADACHE AND RADIAL ARTERY DIAMETER DURING A 7 HOUR INTRAVENOUS-INFUSION OF NITROGLYCERIN

被引:22
作者
IVERSEN, HK [1 ]
NIELSEN, TH [1 ]
TFELTHANSEN, P [1 ]
OLESEN, J [1 ]
机构
[1] BISPEBJERG HOSP,DEPT NEUROL,DK-2400 COPENHAGEN,DENMARK
关键词
NITROGLYCERIN; HEADACHE; TOLERANCE; NITRIC OXIDE; ARTERIAL RESPONSES; ULTRASOUND;
D O I
10.1007/BF00315279
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nitroglycerin-(NTG)-induced headache and dilatation of the radial artery were followed in a double blind, randomized, placebo-controlled, cross-over study in 6 healthy volunteers. NTGO.5 mug.kg-1.min-1 or saline were infused IV for 7 h, and subsequently the infusion rate was doubled for 10 min. The radial artery diameter was measured repeatedly with high frequency ultrasound and pain was scored using a 10 point verbal scale. After 5 min of NTG infusion both headache and the arterial diameter differed significantly from baseline, and no further significant change occurred. The intensity of the headache was mild to medium (median headache score 3, range 1-7). The mean dilatation of the radial artery was 36%. The dilatation in each individual, was stable over time, both during NTG and placebo, and it did not change with the double infusion rate. The headache score in each individual was more fluctuan. No tolerance either to the NTG-induced headache or arterial dilatation was observed.
引用
收藏
页码:47 / 50
页数:4
相关论文
共 20 条
[1]  
ANDERSEN B, 1984, PROBLEMS P SIGNIFICA, P63
[2]   ADMINISTRATION SET SUITABLE FOR USE WITH INTRAVENOUS NITROGLYCERIN [J].
BAASKE, DM ;
AMANN, AH ;
KARNATZ, NN ;
WONG, J ;
WAGENKNECHT, DM ;
CARTER, JE ;
STOLL, RG .
AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1982, 39 (01) :121-122
[3]  
BOGAERT MG, 1968, ARCH INT PHARMACOD T, V2, P458
[4]   MIGRAINE DIAGNOSTICS WITH SPECIAL REFERENCE TO PHARMACOLOGICAL TESTS [J].
DALSGAARDNIELSEN, T .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1955, 7 (4-6) :312-322
[5]   BUCCAL VERSUS INTRAVENOUS NITROGLYCERIN IN UNSTABLE ANGINA-PECTORIS [J].
DELLBORG, M ;
GUSTAFSSON, G ;
SWEDBERG, K .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1991, 41 (01) :5-9
[6]   NITROGLYCERIN AS A PROVOCATIVE AGENT IN CLUSTER HEADACHE [J].
EKBOM, K .
ARCHIVES OF NEUROLOGY, 1968, 19 (05) :487-&
[7]  
FLETCHER A, 1988, LANCET, V2, P4
[8]  
HANSEN HJ, 1970, DAN MED BULL, V17, P226
[9]   PLASMA-CONCENTRATIONS AND HEMODYNAMIC-EFFECTS OF NITROGLYCERIN DURING AND AFTER INTRAVENOUS-INFUSION IN HEALTHY-VOLUNTEERS [J].
IMHOF, PR ;
SIEBER, A ;
HODLER, J ;
MULLER, P ;
OTT, B ;
FANKHAUSER, P ;
CHU, LC ;
GERARDIN, A .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 23 (02) :99-106
[10]   N-ACETYLCYSTEINE ENHANCES NITROGLYCERIN-INDUCED HEADACHE AND CRANIAL ARTERIAL RESPONSES [J].
IVERSEN, HK .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1992, 52 (02) :125-133