ANOMALOUS LATERAL SULCUS ASYMMETRY AND COGNITIVE FUNCTION IN 1ST-EPISODE SCHIZOPHRENIA

被引:137
作者
HOFF, AL
RIORDAN, H
ODONNELL, D
STRITZKE, P
NEALE, C
BOCCIO, A
ANAND, AK
DELISI, LE
机构
[1] SUNY STONY BROOK,HLTH SCI CTR,DEPT PSYCHIAT,SCHIZOPHRENIA RES PROGRAM,RM T-10,STONY BROOK,NY 11794
[2] NAPA STATE HOSP,BIOL PSYCHIAT TREATMENT & RES CTR,IMOLA,CA 94558
[3] STANFORD UNIV,DEPT PSYCHIAT,STANFORD,CA 94305
[4] UNIV PENN,DEPT PSYCHIAT,BRAIN & BEHAV LAB,PHILADELPHIA,PA 19104
[5] KINGS PK PSYCHIAT CTR,SCHIZOPHRENIA RES PROGRAM,KINGS PK,NY
[6] MT SINAI MED CTR,DEPT RADIOL,NEW YORK,NY 10029
[7] LONG ISL DIAGNOST IMAGING CTR,LONG ISL,NY
关键词
D O I
10.1093/schbul/18.2.257
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
This study examines the cognitive functioning of first-episode schizophreniform patients within several weeks of hospitalization and at 2 years into the illness. Differences between patients and controls are also reported for measurements of the length of the lateral sulcus, which borders the planum temporale, an area of the brain integral to language function. Neuropsychological test results are also correlated to magnetic resonance imaging structural variables at the time of first hospitalization. Findings on neuropsychological summary scales reveal a diffuse pattern of cognitive impairment in schizophreniform patients compared to controls, which appears to improve over time. An atypical pattern of anatomic lateral symmetry is found in female schizophreniform patients, with females appearing to have a reduction in the normally occurring left greater than right length of the lateral sulcus. Such atypical asymmetry of the lateral sulcus is also associated with better cognitive function, particularly in schizophreniform patients. These findings suggest that atypical lateralization in an area critical to language function may be related to cognitive function in schizophreniform illness.
引用
收藏
页码:257 / 268
页数:12
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