SYNTHESES OF NO-CARRIER-ADDED (NCA) [F-18] FLUOROALKYL HALIDES AND THEIR APPLICATION IN THE SYNTHESES OF [F-18] FLUOROALKYL DERIVATIVES OF NEUROTRANSMITTER RECEPTOR ACTIVE COMPOUNDS

被引：34

作者：

SHIUE, CY

BAI, LQ

TENG, RR

WOLF, AP

机构：

[1] INST ATOM ENERGY, BEIJING, PEOPLES R CHINA

[2] ACAD SINICA, INST MODERN PHYS, LANZHOU, PEOPLES R CHINA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1987年 / 24卷 / 01期

关键词：

D O I：

10.1002/jlcr.2580240108

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleophilic aliphatic substitution of alkyl halides, 1, [(CH2)nX2 (n = 2, 3; X = Br, I)], with NCA K[18F]/Kryptofix 2.2.2 in CH3CN gave the corresponding NCA [18F]fluoroalkyl halides 2 in 30-40% yields. The factors which influence the yield of 2 were compared. N-Alkylation of several neurotransmitter receptor active amides and amines with this reagent gave the corresponding NCA N-[18F]fluoroalkyl derivatives (3-6) in 20-60% yield.

引用

页码：55 / 64

页数：10

共 19 条

[1] [F-18] N-METHYLSPIROPERIDOL - THE RADIOLIGAND OF CHOICE FOR PETT STUDIES OF THE DOPAMINE RECEPTOR IN HUMAN-BRAIN [J].

ARNETT, CD ;

FOWLER, JS ;

WOLF, AP ;

SHIUE, CY ;

MCPHERSON, DW .

LIFE SCIENCES, 1985, 36 (14) :1359-1366

[2]

BOHME H, 1970, CHEM BER-RECL, V103, P104

[3]

CHI DY, 1986, J FLUORINE CHEM, V31, P99

[4]

COENEN HH, 1985, J NUCL MED, V26, pP37

[5] PREPARATION OF C-11-LABELLED RACLOPRIDE, A NEW POTENT DOPAMINE RECEPTOR ANTAGONIST - PRELIMINARY PET STUDIES OF CEREBRAL DOPAMINE-RECEPTORS IN THE MONKEY [J].

EHRIN, E ;

FARDE, L ;

DEPAULIS, T ;

ERIKSSON, L ;

GREITZ, T ;

JOHNSTROM, P ;

LITTON, JE ;

NILSSON, JLG ;

SEDVALL, G ;

STONEELANDER, S ;

OGREN, SO .

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1985, 36 (04) :269-&

[6]

FELIU AL, 1985, RES COMMUN CHEM PATH, V49, P323

[7]

FOWLER JS, 1982, NASNS3201 NAT AC SCI

[8]

HOFFMANN FW, 1950, J ORG CHEM, V15, P425, DOI DOI 10.1021/JO01148A031

[9]

IWATA R, 1979, INT J APPL RADIAT IS, V30, P194, DOI 10.1016/0020-708X(79)90134-0

[10]

JOHNSON AP, 1964, J CHEM SOC, P520

← 1 2 →