ANTIGENIC VARIATION OF MOLECULARLY CLONED SIV(MAC)239 DURING PERSISTENT INFECTION IN A RHESUS MACAQUE

被引：24

作者：

JOAG, SV ^{[1
]}

ANDERSON, MG ^{[1
]}

CLEMENTS, JE ^{[1
]}

MCENTEE, MF ^{[1
]}

SHARMA, DP ^{[1
]}

ADAMS, RJ ^{[1
]}

NARAYAN, O ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DIV COMPARAT MED,BALTIMORE,MD 21205

来源：

VIROLOGY | 1993年 / 195卷 / 02期

关键词：

D O I：

10.1006/viro.1993.1390

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Eight rhesus macaques inoculated with molecularly cloned SIVmac239 developed viremia and virus-binding antibod-ies, but only one (macaque 2D) developed neutralizing antibodies to the virus. Viremia persisted in macaque 2D even in the presence of neutralizing antibodies. Neutralizing antibodies in the plasma collected from macaque 2D late in infection neutralized virus isolated early in infection. In contrast, these antibodies failed to neutralize the plasma viruses isolated after the appearance of neutralizing antibodies. Only antigenic variants were isolated from blood, spleen, and lymph nodes. Viruses isolated from other macaques that did not develop neutralizing antibodies were neutralized by 2D serum and were of the parental (SIVmac239) phenotype. The variant viruses maintained their strict tropism for lymphocytes, similar to the parental virus. © 1993 Academic Press. All rights reserved.

引用

页码：406 / 412

页数：7

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