REDUCTION OF FLURAZEPAM ANTISEIZURE EFFICACY PERSISTS AFTER STRESS

被引：6

作者：

MASTROPAOLO, J

PARK, CH

NORRIS, DO

OCONNOR, DA

LUKACS, LG

DEUTSCH, SI

机构：

[1] DEPT VET AFFAIRS MED CTR,PSYCHIAT SERV 116A,50 IRVING ST NW,WASHINGTON,DC 20422

[2] AMERICAN UNIV,DEPT PSYCHOL,WASHINGTON,DC 20016

[3] GEORGETOWN UNIV,SCH MED,DEPT PSYCHIAT,WASHINGTON,DC 20007

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 42卷 / 04期

关键词：

STRESS; FLURAZEPAM; SEIZURES;

D O I：

10.1016/0091-3057(92)90014-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Twenty-four hours after mice were forced to swim for up to 10 min in cold (6-degrees-C) water, the ability of flurazepam to antagonize the electrical precipitation of seizures was reduced. This stress-induced reduction in flurazepam's antiseizure efficacy persisted for at least 72 h; but was absent 1 week after the single session of swim stress. The data may be relevant to stress-related psychiatric disorders and suggest that the therapeutic efficacy of benzodiazepines may be altered after a severe stress.

引用

页码：681 / 684

页数：4

共 11 条

[1]

Barnard E A, 1988, Adv Exp Med Biol, V236, P31

[2] PROFOUND STRESS-INDUCED ALTERATIONS IN FLURAZEPAMS ANTISEIZURE EFFICACY CAN BE ATTENUATED [J].